The use of pentafluorophenyl derivatives for the 18F labelling of proteins

L. W. Herman, A. J. Fischman, R. G. Tompkins, R. N. Hanson, C. Byon, H. W. Strauss, D. R. Elmaleh

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

A simple, one-step method for the radiolabelling of proteins with 18F is described. A series of pentafluorophenyl derivatives were synthesized and tested for 18F exchange using tetrabutylammonium-[18F]fluoride in DMSO, with microwave heating. A number of the compounds examined incorporated 18F quickly and in high yield. Two compounds, pentafluorobenzaldehyde and 2,3,5,6-tetrafluorophenyl-pentafluorobenzoate, were used to label HSA in good yield. The methods produce low specific activity labelled proteins, but are fast. The yields are reasonable and the reagents do not require a separate modification or activation step for protein labelling.

Original languageEnglish
Pages (from-to)1005-1010
Number of pages6
JournalNuclear Medicine and Biology
Volume21
Issue number7
DOIs
StatePublished - Oct 1994
Externally publishedYes

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