TY - JOUR
T1 - The use of antiepileptic drugs in paediatric neurosurgical conditions
AU - Themistocleous, Marios S.
AU - Giakoumettis, Dimitrios
AU - Margetis, Konstantinos
AU - Alexiou, George A.
AU - Stranjalis, George
N1 - Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017
Y1 - 2017
N2 - Background: Epileptic seizures are a relatively common problem in pediatric neurosurgery that can have physical, mental and/or behavioral implications. Pediatric neurosurgery is involved in the treatment of secondary epilepsy, which is mainly associated with brain tumors, traumatic brain injury and intracranial vascular malformations. Objective: The aim of this article is to review the current literature for commonly used antiepileptic drugs in pediatric neurosurgery and offer an updated view on epilepsy treatment with antiepileptic drugs in the most commonly encountered neurosurgical entities in the pediatric population. Methods and Materials: Current literature has been reviewed for epilepsy, antiepileptic drugs and common neurosurgical conditions in children that cause seizures and/or epilepsy. Epidemiological features, epileptogenesis and treatment have been thoroughly examined. Conclusion: The most common neurosurgical conditions that cause seizures and/or epilepsy in the pediatric population are brain tumors and traumatic brain injury. Newer antiepileptic drugs are powerful instruments in the management of epilepsy and they improve the quality of life of patients as well as decrease the epilepsy associated morbidity.
AB - Background: Epileptic seizures are a relatively common problem in pediatric neurosurgery that can have physical, mental and/or behavioral implications. Pediatric neurosurgery is involved in the treatment of secondary epilepsy, which is mainly associated with brain tumors, traumatic brain injury and intracranial vascular malformations. Objective: The aim of this article is to review the current literature for commonly used antiepileptic drugs in pediatric neurosurgery and offer an updated view on epilepsy treatment with antiepileptic drugs in the most commonly encountered neurosurgical entities in the pediatric population. Methods and Materials: Current literature has been reviewed for epilepsy, antiepileptic drugs and common neurosurgical conditions in children that cause seizures and/or epilepsy. Epidemiological features, epileptogenesis and treatment have been thoroughly examined. Conclusion: The most common neurosurgical conditions that cause seizures and/or epilepsy in the pediatric population are brain tumors and traumatic brain injury. Newer antiepileptic drugs are powerful instruments in the management of epilepsy and they improve the quality of life of patients as well as decrease the epilepsy associated morbidity.
KW - Antiepileptic drugs
KW - Epileptic seizures
KW - Neurosurgery
KW - Pediatric brain tumor
KW - Pediatric intracranial vascular malformations
KW - Pediatric traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=85046851600&partnerID=8YFLogxK
U2 - 10.2174/1381612823666171031101146
DO - 10.2174/1381612823666171031101146
M3 - Review article
C2 - 29086675
AN - SCOPUS:85046851600
SN - 1381-6128
VL - 23
SP - 6488
EP - 6504
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 42
ER -