The 'ubiquitous' reality of vector immunology

Maiara S. Severo, Olivia S. Sakhon, Anthony Choy, Kimberly D. Stephens, Joao H.F. Pedra

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Ubiquitination (ubiquitylation) is a common protein modification that regulates a multitude of processes within the cell. This modification is typically accomplished through the covalent binding of ubiquitin to a lysine residue onto a target protein and is catalysed by the presence of three enzymes: an activating enzyme (E1), ubiquitin-conjugating enzyme (E2) and ubiquitin-protein ligase (E3). In recent years, ubiquitination has risen as a major signalling regulator of immunity and microbial pathogenesis in the mammalian system. Still, little is known about how ubiquitin relates specifically to vector immunology. Here, we provide a brief overview of ubiquitin biochemistry and describe how ubiquitination regulates immune responses in arthropods of medical relevance. We also discuss scientific gaps in the literature and suggest that, similar to mammals, ubiquitin is a major regulator of immunity in medically important arthropods.

Original languageEnglish
Pages (from-to)1070-1078
Number of pages9
JournalCellular Microbiology
Volume15
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

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