The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors

Tammy L. Dellovade; John Chan; Bjorn Vennstrom; Douglas Forrest; Donald W. Pfaff

doi:10.1038/74846

The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors

Tammy L. Dellovade, John Chan, Bjorn Vennstrom, Douglas Forrest, Donald W. Pfaff

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66 Scopus citations

Abstract

The two genes coding for thyroid hormone receptors (TR) α1 and β have opposite effects on female sex behaviors. Deletion of TRα1 reduced them, whereas deletion of TRβ actually increased them. These results could not be attributed to altered levels of hormones in the blood, general alterations in estrogen responsiveness or altered general activity. Instead, they indicate a previously unknown molecular mechanism upon which the two TR genes exert opposite influences.

Original language	English
Pages (from-to)	472-475
Number of pages	4
Journal	Nature Neuroscience
Volume	3
Issue number	5
DOIs	https://doi.org/10.1038/74846
State	Published - May 2000

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abstract = "The two genes coding for thyroid hormone receptors (TR) α1 and β have opposite effects on female sex behaviors. Deletion of TRα1 reduced them, whereas deletion of TRβ actually increased them. These results could not be attributed to altered levels of hormones in the blood, general alterations in estrogen responsiveness or altered general activity. Instead, they indicate a previously unknown molecular mechanism upon which the two TR genes exert opposite influences.",

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The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors

Abstract

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