The Tumor Microenvironment and Immunotherapy in Prostate and Bladder Cancer

Sujit S. Nair, Rachel Weil, Zachary Dovey, Avery Davis, Ashutosh K. Tewari

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Bladder cancer has been successfully treated with immunotherapy, whereas prostate cancer is a cold tumor with inadequate immune-related treatment response. A greater understanding of the tumor microenvironment and methods for harnessing the immune system to address tumor growth will be needed to improve immunotherapies for both prostate and bladder cancer. Here, we provide an overview of prostate and bladder cancer, including fundamental aspects of the disease and treatment, the elaborate cellular makeup of the tumor microenvironment, and methods for exploiting relevant pathways to develop more effective treatments.

Original languageEnglish
Pages (from-to)e17-e54
JournalUrologic Clinics of North America
Volume47
Issue number4
DOIs
StatePublished - Nov 2020

Keywords

  • Bladder cancer
  • Immunoediting
  • Immunotherapy
  • Neoadjuvant treatment
  • Prostate cancer
  • Tumor microenvironment
  • Vaccines

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