The Tube Versus Trabeculectomy Study: Interpretation of results and application to clinical practice

Steven Gedde; Douglas Anderson; Donald Budenz; Madeline Del Calvo; Ivette DePool; Francisco Fantes; David Greenfield; Jessica Hochberg; Elizabeth Hodapp; Richard Lee; Alexia Marcellino; Paul Palmberg; Richard Parrish; Leon Herndon; Pratap Challa; Cecile Santiago-Turla; Darrell WuDunn; Geoffrey Emerick; Dale Heuer; Alexander Kent; Carol Bradham; Lisa Langdale; Keith Barton; Francesca Amalfitano; Poornima Rai; Paul Sidoti; Amy Gedal; James Luayon; Roma Ovase; Katy Tai; Quang Nguyen; Steven Shields; Kevin Anderson; Frank Moya; James Brandt; Michele Lim; Marilyn Sponzo; Mark Sherwood; Gregory Skuta,; Jason Jobson; Lisa Ogilbee; Adam Reynolds; Steven Sarkisian; Rohit Varma; Robert Feldman; Laura Baker; Nicholas Bell; Jo Lene Carranza; Brian Francis; Bruce Prum; Todd Perkins,; Paul Kaufman; Barbara Soderling; William Feuer; Luz Londono; Joyce Schiffman; Wei Shi; Philip Chen; Kuldev Singh; George Spaeth; Martha Wright; Gregory Skuta

doi:10.1097/ICU.0b013e32834ff2d1

The Tube Versus Trabeculectomy Study: Interpretation of results and application to clinical practice

Steven Gedde, Douglas Anderson, Donald Budenz, Madeline Del Calvo, Ivette DePool, Francisco Fantes, David Greenfield, Jessica Hochberg, Elizabeth Hodapp, Richard Lee, Alexia Marcellino, Paul Palmberg, Richard Parrish, Leon Herndon, Pratap Challa, Cecile Santiago-Turla, Darrell WuDunn, Geoffrey Emerick, Dale Heuer, Alexander KentCarol Bradham, Lisa Langdale, Keith Barton, Francesca Amalfitano, Poornima Rai, Paul Sidoti, Amy Gedal, James Luayon, Roma Ovase, Katy Tai, Quang Nguyen, Steven Shields, Kevin Anderson, Frank Moya, James Brandt, Michele Lim, Marilyn Sponzo, Mark Sherwood, Gregory Skuta,, Jason Jobson, Lisa Ogilbee, Adam Reynolds, Steven Sarkisian, Rohit Varma, Robert Feldman, Laura Baker, Nicholas Bell, Jo Lene Carranza, Brian Francis, Bruce Prum, Todd Perkins,, Paul Kaufman, Barbara Soderling, William Feuer, Luz Londono, Joyce Schiffman, Wei Shi, Philip Chen, Kuldev Singh, George Spaeth, Martha Wright, Gregory Skuta

Research output: Contribution to journal › Review article › peer-review

121 Scopus citations

Abstract

PURPOSE OF REVIEW: The Tube Versus Trabeculectomy (TVT) Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube-shunt surgery to trabeculectomy with mitomycin C (MMC) in eyes with previous cataract and/or failed glaucoma surgery. This article interprets results from the TVT Study and applies them to clinical practice. RECENT FINDINGS: Both tube-shunt surgery and trabeculectomy with MMC produced intraocular pressure (IOP) reduction to the low teens throughout the 5-year duration of the study. Tube-shunt surgery was associated with use of more glaucoma medications than trabeculectomy with MMC during the first 2 years of the study, but medical therapy equalized with longer follow-up. Trabeculectomy with MMC had higher rates of surgical failure and reoperation for glaucoma compared with tube-shunt surgery. Vision loss occurred at a similar rate with the two surgical procedures. Early complications were more frequent after trabeculectomy with MMC relative to tube-shunt surgery, but both procedures had similar rates of late postoperative complications and serious complications. SUMMARY: Tube-shunt surgery and trabeculectomy with MMC are both viable surgical options for managing glaucoma in patients who have undergone prior cataract and/or failed filtering surgery. Results of the TVT Study support the expanding use of tube shunts beyond refractory glaucomas.

Original language	English
Pages (from-to)	118-126
Number of pages	9
Journal	Current Opinion in Ophthalmology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1097/ICU.0b013e32834ff2d1
State	Published - 1 Mar 2012
Externally published	Yes

Keywords

Glaucoma surgery
Trabeculectomy
Tube shunt

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Gedde, S., Anderson, D., Budenz, D., Del Calvo, M., DePool, I., Fantes, F., Greenfield, D., Hochberg, J., Hodapp, E., Lee, R., Marcellino, A., Palmberg, P., Parrish, R., Herndon, L., Challa, P., Santiago-Turla, C., WuDunn, D., Emerick, G., Heuer, D., ... Skuta, G. (2012). The Tube Versus Trabeculectomy Study: Interpretation of results and application to clinical practice. Current Opinion in Ophthalmology, 23(2), 118-126. https://doi.org/10.1097/ICU.0b013e32834ff2d1

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title = "The Tube Versus Trabeculectomy Study: Interpretation of results and application to clinical practice",

abstract = "PURPOSE OF REVIEW: The Tube Versus Trabeculectomy (TVT) Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube-shunt surgery to trabeculectomy with mitomycin C (MMC) in eyes with previous cataract and/or failed glaucoma surgery. This article interprets results from the TVT Study and applies them to clinical practice. RECENT FINDINGS: Both tube-shunt surgery and trabeculectomy with MMC produced intraocular pressure (IOP) reduction to the low teens throughout the 5-year duration of the study. Tube-shunt surgery was associated with use of more glaucoma medications than trabeculectomy with MMC during the first 2 years of the study, but medical therapy equalized with longer follow-up. Trabeculectomy with MMC had higher rates of surgical failure and reoperation for glaucoma compared with tube-shunt surgery. Vision loss occurred at a similar rate with the two surgical procedures. Early complications were more frequent after trabeculectomy with MMC relative to tube-shunt surgery, but both procedures had similar rates of late postoperative complications and serious complications. SUMMARY: Tube-shunt surgery and trabeculectomy with MMC are both viable surgical options for managing glaucoma in patients who have undergone prior cataract and/or failed filtering surgery. Results of the TVT Study support the expanding use of tube shunts beyond refractory glaucomas.",

keywords = "Glaucoma surgery, Trabeculectomy, Tube shunt",

author = "Steven Gedde and Douglas Anderson and Donald Budenz and {Del Calvo}, Madeline and Ivette DePool and Francisco Fantes and David Greenfield and Jessica Hochberg and Elizabeth Hodapp and Richard Lee and Alexia Marcellino and Paul Palmberg and Richard Parrish and Leon Herndon and Pratap Challa and Cecile Santiago-Turla and Darrell WuDunn and Geoffrey Emerick and Dale Heuer and Alexander Kent and Carol Bradham and Lisa Langdale and Keith Barton and Francesca Amalfitano and Poornima Rai and Paul Sidoti and Amy Gedal and James Luayon and Roma Ovase and Katy Tai and Quang Nguyen and Steven Shields and Kevin Anderson and Frank Moya and James Brandt and Michele Lim and Marilyn Sponzo and Mark Sherwood and Gregory Skuta, and Jason Jobson and Lisa Ogilbee and Adam Reynolds and Steven Sarkisian and Rohit Varma and Robert Feldman and Laura Baker and Nicholas Bell and Carranza, {Jo Lene} and Brian Francis and Bruce Prum and Todd Perkins, and Paul Kaufman and Barbara Soderling and William Feuer and Luz Londono and Joyce Schiffman and Wei Shi and Philip Chen and Kuldev Singh and George Spaeth and Martha Wright and Gregory Skuta",

year = "2012",

month = mar,

day = "1",

doi = "10.1097/ICU.0b013e32834ff2d1",

language = "English",

volume = "23",

pages = "118--126",

journal = "Current Opinion in Ophthalmology",

issn = "1040-8738",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "2",

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Gedde, S, Anderson, D, Budenz, D, Del Calvo, M, DePool, I, Fantes, F, Greenfield, D, Hochberg, J, Hodapp, E, Lee, R, Marcellino, A, Palmberg, P, Parrish, R, Herndon, L, Challa, P, Santiago-Turla, C, WuDunn, D, Emerick, G, Heuer, D, Kent, A, Bradham, C, Langdale, L, Barton, K, Amalfitano, F, Rai, P, Sidoti, P, Gedal, A, Luayon, J, Ovase, R, Tai, K, Nguyen, Q, Shields, S, Anderson, K, Moya, F, Brandt, J, Lim, M, Sponzo, M, Sherwood, M, Skuta, G, Jobson, J, Ogilbee, L, Reynolds, A, Sarkisian, S, Varma, R, Feldman, R, Baker, L, Bell, N, Carranza, JL, Francis, B, Prum, B, Perkins, T, Kaufman, P, Soderling, B, Feuer, W, Londono, L, Schiffman, J, Shi, W, Chen, P, Singh, K, Spaeth, G, Wright, M & Skuta, G 2012, 'The Tube Versus Trabeculectomy Study: Interpretation of results and application to clinical practice', Current Opinion in Ophthalmology, vol. 23, no. 2, pp. 118-126. https://doi.org/10.1097/ICU.0b013e32834ff2d1

TY - JOUR

T1 - The Tube Versus Trabeculectomy Study

T2 - Interpretation of results and application to clinical practice

AU - Gedde, Steven

AU - Anderson, Douglas

AU - Budenz, Donald

AU - Del Calvo, Madeline

AU - DePool, Ivette

AU - Fantes, Francisco

AU - Greenfield, David

AU - Hochberg, Jessica

AU - Hodapp, Elizabeth

AU - Lee, Richard

AU - Marcellino, Alexia

AU - Palmberg, Paul

AU - Parrish, Richard

AU - Herndon, Leon

AU - Challa, Pratap

AU - Santiago-Turla, Cecile

AU - WuDunn, Darrell

AU - Emerick, Geoffrey

AU - Heuer, Dale

AU - Kent, Alexander

AU - Bradham, Carol

AU - Langdale, Lisa

AU - Barton, Keith

AU - Amalfitano, Francesca

AU - Rai, Poornima

AU - Sidoti, Paul

AU - Gedal, Amy

AU - Luayon, James

AU - Ovase, Roma

AU - Tai, Katy

AU - Nguyen, Quang

AU - Shields, Steven

AU - Anderson, Kevin

AU - Moya, Frank

AU - Brandt, James

AU - Lim, Michele

AU - Sponzo, Marilyn

AU - Sherwood, Mark

AU - Skuta,, Gregory

AU - Jobson, Jason

AU - Ogilbee, Lisa

AU - Reynolds, Adam

AU - Sarkisian, Steven

AU - Varma, Rohit

AU - Feldman, Robert

AU - Baker, Laura

AU - Bell, Nicholas

AU - Carranza, Jo Lene

AU - Francis, Brian

AU - Prum, Bruce

AU - Perkins,, Todd

AU - Kaufman, Paul

AU - Soderling, Barbara

AU - Feuer, William

AU - Londono, Luz

AU - Schiffman, Joyce

AU - Shi, Wei

AU - Chen, Philip

AU - Singh, Kuldev

AU - Spaeth, George

AU - Wright, Martha

AU - Skuta, Gregory

PY - 2012/3/1

Y1 - 2012/3/1

N2 - PURPOSE OF REVIEW: The Tube Versus Trabeculectomy (TVT) Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube-shunt surgery to trabeculectomy with mitomycin C (MMC) in eyes with previous cataract and/or failed glaucoma surgery. This article interprets results from the TVT Study and applies them to clinical practice. RECENT FINDINGS: Both tube-shunt surgery and trabeculectomy with MMC produced intraocular pressure (IOP) reduction to the low teens throughout the 5-year duration of the study. Tube-shunt surgery was associated with use of more glaucoma medications than trabeculectomy with MMC during the first 2 years of the study, but medical therapy equalized with longer follow-up. Trabeculectomy with MMC had higher rates of surgical failure and reoperation for glaucoma compared with tube-shunt surgery. Vision loss occurred at a similar rate with the two surgical procedures. Early complications were more frequent after trabeculectomy with MMC relative to tube-shunt surgery, but both procedures had similar rates of late postoperative complications and serious complications. SUMMARY: Tube-shunt surgery and trabeculectomy with MMC are both viable surgical options for managing glaucoma in patients who have undergone prior cataract and/or failed filtering surgery. Results of the TVT Study support the expanding use of tube shunts beyond refractory glaucomas.

AB - PURPOSE OF REVIEW: The Tube Versus Trabeculectomy (TVT) Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube-shunt surgery to trabeculectomy with mitomycin C (MMC) in eyes with previous cataract and/or failed glaucoma surgery. This article interprets results from the TVT Study and applies them to clinical practice. RECENT FINDINGS: Both tube-shunt surgery and trabeculectomy with MMC produced intraocular pressure (IOP) reduction to the low teens throughout the 5-year duration of the study. Tube-shunt surgery was associated with use of more glaucoma medications than trabeculectomy with MMC during the first 2 years of the study, but medical therapy equalized with longer follow-up. Trabeculectomy with MMC had higher rates of surgical failure and reoperation for glaucoma compared with tube-shunt surgery. Vision loss occurred at a similar rate with the two surgical procedures. Early complications were more frequent after trabeculectomy with MMC relative to tube-shunt surgery, but both procedures had similar rates of late postoperative complications and serious complications. SUMMARY: Tube-shunt surgery and trabeculectomy with MMC are both viable surgical options for managing glaucoma in patients who have undergone prior cataract and/or failed filtering surgery. Results of the TVT Study support the expanding use of tube shunts beyond refractory glaucomas.

KW - Glaucoma surgery

KW - Trabeculectomy

KW - Tube shunt

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U2 - 10.1097/ICU.0b013e32834ff2d1

DO - 10.1097/ICU.0b013e32834ff2d1

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AN - SCOPUS:84857236207

SN - 1040-8738

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SP - 118

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JO - Current Opinion in Ophthalmology

JF - Current Opinion in Ophthalmology

IS - 2

ER -

The Tube Versus Trabeculectomy Study: Interpretation of results and application to clinical practice

Abstract

Keywords

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