The treatment of rejection: A trial of acetylsalicylic acid, dipyridamole, and heparin1

C. R. P. George; Sherrill J. Slichter; Leonard J. Quadracci; Gerald M. Kenny; Melvin B. Dennis; Gary E. Striker; Laurence A. Harker

doi:10.1097/00007890-197509000-00008

The treatment of rejection: A trial of acetylsalicylic acid, dipyridamole, and heparin¹

C. R. P. George, Sherrill J. Slichter, Leonard J. Quadracci, Gerald M. Kenny, Melvin B. Dennis, Gary E. Striker, Laurence A. Harker

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Serial studies of platelet and fibrinogen survival were performed in 26 nonimmuno- suppressed dogs after allogenic renal transplant operations. Treatment with acetylsali-cylic acid, dipyridamole, and heparin failed to improve the selective platelet destruction which occurred in untreated animals, and it did not improve postoperative longevity. There was a high incidence of postoperative wound and intrarenai hemorrhage after heparin treatment. These results are consistent with the hypothesis that platelet destruction is a consequence rather than the cause of acute graft rejection, and it is concluded that antithrombotic therapy is not of practical benefit in preventing acute rejection.

Original language	English
Pages (from-to)	237-240
Number of pages	4
Journal	Transplantation
Volume	20
Issue number	3
DOIs	https://doi.org/10.1097/00007890-197509000-00008
State	Published - Sep 1975
Externally published	Yes

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@article{7226ac9fdc214ddd9495b42b7d6ff6ad,

title = "The treatment of rejection: A trial of acetylsalicylic acid, dipyridamole, and heparin1",

abstract = "Serial studies of platelet and fibrinogen survival were performed in 26 nonimmuno- suppressed dogs after allogenic renal transplant operations. Treatment with acetylsali-cylic acid, dipyridamole, and heparin failed to improve the selective platelet destruction which occurred in untreated animals, and it did not improve postoperative longevity. There was a high incidence of postoperative wound and intrarenai hemorrhage after heparin treatment. These results are consistent with the hypothesis that platelet destruction is a consequence rather than the cause of acute graft rejection, and it is concluded that antithrombotic therapy is not of practical benefit in preventing acute rejection.",

author = "{P. George}, {C. R.} and Slichter, {Sherrill J.} and Quadracci, {Leonard J.} and Kenny, {Gerald M.} and Dennis, {Melvin B.} and Striker, {Gary E.} and Harker, {Laurence A.}",

year = "1975",

month = sep,

doi = "10.1097/00007890-197509000-00008",

language = "English",

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pages = "237--240",

journal = "Transplantation",

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publisher = "Lippincott Williams and Wilkins",

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T1 - The treatment of rejection

T2 - A trial of acetylsalicylic acid, dipyridamole, and heparin1

AU - P. George, C. R.

AU - Slichter, Sherrill J.

AU - Quadracci, Leonard J.

AU - Kenny, Gerald M.

AU - Dennis, Melvin B.

AU - Striker, Gary E.

AU - Harker, Laurence A.

PY - 1975/9

Y1 - 1975/9

N2 - Serial studies of platelet and fibrinogen survival were performed in 26 nonimmuno- suppressed dogs after allogenic renal transplant operations. Treatment with acetylsali-cylic acid, dipyridamole, and heparin failed to improve the selective platelet destruction which occurred in untreated animals, and it did not improve postoperative longevity. There was a high incidence of postoperative wound and intrarenai hemorrhage after heparin treatment. These results are consistent with the hypothesis that platelet destruction is a consequence rather than the cause of acute graft rejection, and it is concluded that antithrombotic therapy is not of practical benefit in preventing acute rejection.

AB - Serial studies of platelet and fibrinogen survival were performed in 26 nonimmuno- suppressed dogs after allogenic renal transplant operations. Treatment with acetylsali-cylic acid, dipyridamole, and heparin failed to improve the selective platelet destruction which occurred in untreated animals, and it did not improve postoperative longevity. There was a high incidence of postoperative wound and intrarenai hemorrhage after heparin treatment. These results are consistent with the hypothesis that platelet destruction is a consequence rather than the cause of acute graft rejection, and it is concluded that antithrombotic therapy is not of practical benefit in preventing acute rejection.

UR - http://www.scopus.com/inward/record.url?scp=0016778016&partnerID=8YFLogxK

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DO - 10.1097/00007890-197509000-00008

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SN - 0041-1337

VL - 20

SP - 237

EP - 240

JO - Transplantation

JF - Transplantation

IS - 3

ER -

The treatment of rejection: A trial of acetylsalicylic acid, dipyridamole, and heparin1

Abstract

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The treatment of rejection: A trial of acetylsalicylic acid, dipyridamole, and heparin¹