Abstract
This paper reports a clinical trial of tienilic acid, a new diuretic with uricosuric properties, in 23 patients with milk to moderate hypertension (standing diastolic blood pressure 90-120 mmHg). Tienilic acid was compared with hydrochlorothiazide in a variable-dose, double-blind cross-over study, and the duration of therapy was 8 weeks for each drug. The falls in blood pressure (systolic/diastolic) were: 11/11 mmHg supine and 17/11 mmHg standing for tienilic acid, and 8/12 mmHg supine and 9/17 mmHg standing for hydrochlorothiazide. There were no significant differences between the two drugs in their effect on blood pressure and heart rate, and regarding side-effects and laboratory results, except for serum uric acid levels (mean fall of 1.5 mg/dl with tienilic acid and mean increase of 1.1 mg/l with hydrochlorothiazide).
| Original language | English |
|---|---|
| Pages (from-to) | 1069-1072 |
| Number of pages | 4 |
| Journal | South African Medical Journal |
| Volume | 57 |
| Issue number | 26 |
| State | Published - 1980 |
| Externally published | Yes |