The treatment of aggressive prolactinomas with everolimus

Andrew L. Lin, Eliza B. Geer, Nupur Lala, Gabrielle Page-Wilson, Rajiv Magge, Robert J. Young, Viviane Tabar

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: Aggressive prolactinomas are life-limiting tumors without a standard of care treatment option after the oral alkylator, temozolomide, fails to provide tumor control. Methods: We reviewed an institutional database of pituitary tumors for patients with aggressive prolactinomas who progressed following treatment with a dopamine receptor agonist, radiotherapy and temozolomide. Within this cohort, we identified four patients who were treated with everolimus and we report their response to this therapy. Treatment response was determined by a neuroradiologist, who manually performed volumetric assessment and determined treatment response by Response Assessments in Neuro-Oncology (RANO) criteria. Results: Three of four patients who were treated with everolimus had a biochemical response to therapy and all patients derived a clinically meaningful benefit based upon suppression of tumor growth. While the best overall response as assessed by RANO criteria was stable disease for the four patients, a minor regression in tumor size was appreciated in two of the four patients. Conclusion: Everolimus is an active agent in the treatment of prolactinomas that warrants further investigation.

Original languageEnglish
Pages (from-to)474-481
Number of pages8
JournalPituitary
Volume26
Issue number4
DOIs
StatePublished - Aug 2023
Externally publishedYes

Keywords

  • Aggressive pituitary adenoma
  • Pituitary carcinoma
  • Prolactinoma
  • Targeted therapy

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