The tissue is the issue: Personalized medicine for non-small cell lung cancer

Fred R. Hirsch; Murry W. Wynes; David R. Gandara; Paul A. Bunn

doi:10.1158/1078-0432.CCR-10-2005

The tissue is the issue: Personalized medicine for non-small cell lung cancer

Fred R. Hirsch, Murry W. Wynes, David R. Gandara, Paul A. Bunn

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Abstract

The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, validation, and clinical application to different types of tissue specimens are discussed.

Original language	English
Pages (from-to)	4909-4911
Number of pages	3
Journal	Clinical Cancer Research
Volume	16
Issue number	20
DOIs	https://doi.org/10.1158/1078-0432.CCR-10-2005
State	Published - 15 Oct 2010
Externally published	Yes

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10.1158/1078-0432.CCR-10-2005

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title = "The tissue is the issue: Personalized medicine for non-small cell lung cancer",

abstract = "The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, validation, and clinical application to different types of tissue specimens are discussed.",

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AU - Hirsch, Fred R.

AU - Wynes, Murry W.

AU - Gandara, David R.

AU - Bunn, Paul A.

PY - 2010/10/15

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N2 - The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, validation, and clinical application to different types of tissue specimens are discussed.

AB - The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, validation, and clinical application to different types of tissue specimens are discussed.

UR - https://www.scopus.com/pages/publications/77958072139

U2 - 10.1158/1078-0432.CCR-10-2005

DO - 10.1158/1078-0432.CCR-10-2005

M3 - Review article

C2 - 20926402

AN - SCOPUS:77958072139

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SP - 4909

EP - 4911

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 20

ER -

The tissue is the issue: Personalized medicine for non-small cell lung cancer

Abstract

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