The Thyroid-Stimulating Hormone Receptor: Impact of Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Antibodies on Multimerization, Cleavage, and Signaling

Rauf Latif; Syed A. Morshed; Mone Zaidi; Terry F. Davies

doi:10.1016/j.ecl.2009.01.006

The Thyroid-Stimulating Hormone Receptor: Impact of Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Antibodies on Multimerization, Cleavage, and Signaling

Rauf Latif, Syed A. Morshed, Mone Zaidi, Terry F. Davies

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

The thyroid-stimulating hormone receptor (TSHR) has a central role in thyrocyte function and is also one of the major autoantigens for the autoimmune thyroid diseases. We review the post-translational processing, multimerization, and intramolecular cleavage of TSHR, all of which may modulate its signal transduction. The recent characterization of monoclonal antibodies to the TSHR, including stimulating, blocking, and neutral antibodies, have also revealed unique biologic insights into receptor activation and the variety of these TSHR antibodies may help explain the multiple clinical phenotypes seen in autoimmune thyroid diseases. Knowledge of the structure/function relationship of the TSHR is beginning to provide a greater understanding of thyroid physiology and thyroid autoimmunity.

Original language	English
Pages (from-to)	319-341
Number of pages	23
Journal	Endocrinology and Metabolism Clinics of North America
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.ecl.2009.01.006
State	Published - Jun 2009

Keywords

Autoimmune thyroid disease
Multimerization
Oligomerization
Signaling
TSH receptor
TSHR antibodies

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10.1016/j.ecl.2009.01.006

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title = "The Thyroid-Stimulating Hormone Receptor: Impact of Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Antibodies on Multimerization, Cleavage, and Signaling",

abstract = "The thyroid-stimulating hormone receptor (TSHR) has a central role in thyrocyte function and is also one of the major autoantigens for the autoimmune thyroid diseases. We review the post-translational processing, multimerization, and intramolecular cleavage of TSHR, all of which may modulate its signal transduction. The recent characterization of monoclonal antibodies to the TSHR, including stimulating, blocking, and neutral antibodies, have also revealed unique biologic insights into receptor activation and the variety of these TSHR antibodies may help explain the multiple clinical phenotypes seen in autoimmune thyroid diseases. Knowledge of the structure/function relationship of the TSHR is beginning to provide a greater understanding of thyroid physiology and thyroid autoimmunity.",

keywords = "Autoimmune thyroid disease, Multimerization, Oligomerization, Signaling, TSH receptor, TSHR antibodies",

author = "Rauf Latif and Morshed, {Syed A.} and Mone Zaidi and Davies, {Terry F.}",

note = "Funding Information: Supported in part by DK069713 and DK052464 from National Institute of Diabetes and Digestive and Kidney Diseases, the VA Merit Award Program, and the David Owen Segal Endowment. ",

year = "2009",

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language = "English",

volume = "38",

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The Thyroid-Stimulating Hormone Receptor: Impact of Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Antibodies on Multimerization, Cleavage, and Signaling. / Latif, Rauf ; Morshed, Syed A.; Zaidi, Mone et al.
In: Endocrinology and Metabolism Clinics of North America, Vol. 38, No. 2, 06.2009, p. 319-341.

Research output: Contribution to journal › Review article › peer-review

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AU - Morshed, Syed A.

AU - Zaidi, Mone

AU - Davies, Terry F.

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The Thyroid-Stimulating Hormone Receptor: Impact of Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Antibodies on Multimerization, Cleavage, and Signaling

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Keywords

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