The Thyroid Hormone Receptor β Gene: Structure and Functions in the Brain and Sensory Systems

Thyroid hormone profoundly influences the development of the vertebrate nervous system. The thyroid hormone receptor β gene (Thrb) is a key mediator of many of these actions. The Thrb gene is complex, spanning up to 400 kb in mammals, and differentially expresses distinct receptor subtypes through independent tissue-specific promoters and alternative splicing. These receptors serve a range of functions in the brain as well as particularly sensitive functions in the auditory and visual sensory systems. The Thrb gene illustrates how versatility in neurodevelopmental control can be achieved at the receptor level.