TY - JOUR
T1 - The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
AU - ENIGMA OCD Working Group
AU - Weeland, Cees J.
AU - Kasprzak, Selina
AU - de Joode, Niels T.
AU - Abe, Yoshinari
AU - Alonso, Pino
AU - Ameis, Stephanie H.
AU - Anticevic, Alan
AU - Arnold, Paul D.
AU - Balachander, Srinivas
AU - Banaj, Nerisa
AU - Bargallo, Nuria
AU - Batistuzzo, Marcelo C.
AU - Benedetti, Francesco
AU - Beucke, Jan C.
AU - Bollettini, Irene
AU - Brecke, Vilde
AU - Brem, Silvia
AU - Cappi, Carolina
AU - Cheng, Yuqi
AU - Cho, Kang Ik K.
AU - Costa, Daniel L.C.
AU - Dallaspezia, Sara
AU - Denys, Damiaan
AU - Eng, Goi Khia
AU - Ferreira, Sónia
AU - Feusner, Jamie D.
AU - Fontaine, Martine
AU - Fouche, Jean Paul
AU - Grazioplene, Rachael G.
AU - Gruner, Patricia
AU - He, Mengxin
AU - Hirano, Yoshiyuki
AU - Hoexter, Marcelo Q.
AU - Huyser, Chaim
AU - Hu, Hao
AU - Jaspers-Fayer, Fern
AU - Kathmann, Norbert
AU - Kaufmann, Christian
AU - Kim, Minah
AU - Koch, Kathrin
AU - Bin Kwak, Yoo
AU - Kwon, Jun Soo
AU - Lazaro, Luisa
AU - Li, Chiang shan R.
AU - Lochner, Christine
AU - Marsh, Rachel
AU - Martínez-Zalacaín, Ignacio
AU - Stern, Emily R.
AU - Szeszko, Philip R.
AU - Stein, Dan J.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered (https://osf.io/73dvy) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = −0.15 to −0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.
AB - Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered (https://osf.io/73dvy) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = −0.15 to −0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.
UR - http://www.scopus.com/inward/record.url?scp=85125154377&partnerID=8YFLogxK
U2 - 10.1038/s41398-022-01823-2
DO - 10.1038/s41398-022-01823-2
M3 - Article
C2 - 35190533
AN - SCOPUS:85125154377
SN - 2158-3188
VL - 12
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 70
ER -