The synthesis of 14C‐labeled suicide inactivators of monoamine oxidase

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N‐[3‐(2,4‐dichlorophenoxy)propyl]‐N‐methyl‐2‐propynylamine‐1‐14C (14C‐clorgyline, 1a) and L‐N, α‐dimethyl‐N‐2‐propynyl‐1‐14C‐phenethylamine (14C‐L deprenyl, 1b) were synthesized by the Mannich reaction of 2‐methyl‐3‐butyn‐2‐ol, 14C‐formaldehyde, and secondary amines 3‐(2,4‐dichlorophenoxy)‐N‐methylpropylamine (2a) or L‐N, α‐dimethylphenethylamine (2b) followed by KOH catalyzed elimination of acetone from the respective Mannich base 3a or 3b.

Original languageEnglish
Pages (from-to)435-437
Number of pages3
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number3
StatePublished - 1978
Externally publishedYes


  • C‐clorgyline
  • C‐deprenyl
  • C‐suicide enzyme inactivators


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