TY - JOUR
T1 - The synthesis and evaluation of radioiodinated 14-(iodophenyl)-3-(R,S)methyltetradecanoic acid
AU - Elmaleh, David R.
AU - Livni, Eli
AU - Okada, Robert
AU - Needham, Fang Ling
AU - Schleuederberg, Jeff
AU - Strauss, H. W.
PY - 1985/5
Y1 - 1985/5
N2 - Radiohalogenated fatty acids (FA) labelled with gamma-emitting isotopes have a potentially important application in studies of impaired myocardial perfusion and metabolism. Evaluation of straight-chain fatty acids radiolabelled in different positions on the FA chain has been reported by many groups. In this paper we extended our recent studies using the betamethyl branched-chain fatty acid. The synthesis, labelling and preliminary evaluation of131I- and123I-14-(iodophenyl)-3-(R,S)methyltetradecanoic acid (I-PBMTA) are reported. This radiolabel concentrates in the mouse myocardium with 16% injected dose g-1and 11% injected dose g-1at 15 and 30 min, respectively. The images of the canine heart postinjection indicate a high myocardial extraction of the label with activity retained over an hour. The rate of washout of the activity from the heart was very low. This analogue is a potential agent for myocardial imaging studies.
AB - Radiohalogenated fatty acids (FA) labelled with gamma-emitting isotopes have a potentially important application in studies of impaired myocardial perfusion and metabolism. Evaluation of straight-chain fatty acids radiolabelled in different positions on the FA chain has been reported by many groups. In this paper we extended our recent studies using the betamethyl branched-chain fatty acid. The synthesis, labelling and preliminary evaluation of131I- and123I-14-(iodophenyl)-3-(R,S)methyltetradecanoic acid (I-PBMTA) are reported. This radiolabel concentrates in the mouse myocardium with 16% injected dose g-1and 11% injected dose g-1at 15 and 30 min, respectively. The images of the canine heart postinjection indicate a high myocardial extraction of the label with activity retained over an hour. The rate of washout of the activity from the heart was very low. This analogue is a potential agent for myocardial imaging studies.
UR - http://www.scopus.com/inward/record.url?scp=0021875257&partnerID=8YFLogxK
U2 - 10.1097/00006231-198505000-00007
DO - 10.1097/00006231-198505000-00007
M3 - Article
C2 - 4034126
AN - SCOPUS:0021875257
SN - 0143-3636
VL - 6
SP - 287
EP - 298
JO - Nuclear Medicine Communications
JF - Nuclear Medicine Communications
IS - 5
ER -