The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics

Carlos Andrés Chacón-Martínez, Nadine Kiessling, Moritz Winterhoff, Jan Faix, Thomas Müller-Reichert, Rolf Jessberger

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Background:Precise spatiotemporal rearrangement of the actin cytoskeleton is essential for cell migration and adhesion. Results:SWAP-70 bundles actin filaments and interacts with cofilinin vitroand in murine mast cells. Conclusion:SWAP-70 is a parallel and anti-parallel bundling protein that participates in the organization of F-actin networks. Significance: Identification and characterization of a regulator of F-actin dynamics improve our understanding on the spatiotemporal control of cytoskeletal processes.

Original languageEnglish
Pages (from-to)28687-28703
Number of pages17
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - 4 Oct 2013
Externally publishedYes

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