TY - JOUR
T1 - The Structure of HPK1 Kinase Domain
T2 - To Boldly Go Where No Immuno-Oncology Drugs Have Gone Before
AU - Sawasdikosol, Sansana
AU - Burakoff, Steven
N1 - Publisher Copyright:
© 2018
PY - 2019/1/2
Y1 - 2019/1/2
N2 - In this issue of Structure, Wu et al. (2018) report several apo and small-molecule inhibitor-bound structures of the kinase domain of hematopoietic progenitor kinase 1, a ser/thr kinase that functions as an inhibitor of T cell activation. The studies reveal that the HPK1 kinase domain exists as a domain-swapped dimer.
AB - In this issue of Structure, Wu et al. (2018) report several apo and small-molecule inhibitor-bound structures of the kinase domain of hematopoietic progenitor kinase 1, a ser/thr kinase that functions as an inhibitor of T cell activation. The studies reveal that the HPK1 kinase domain exists as a domain-swapped dimer.
UR - http://www.scopus.com/inward/record.url?scp=85058717628&partnerID=8YFLogxK
U2 - 10.1016/j.str.2018.12.009
DO - 10.1016/j.str.2018.12.009
M3 - Short survey
C2 - 30605659
AN - SCOPUS:85058717628
SN - 0969-2126
VL - 27
SP - 1
EP - 3
JO - Structure
JF - Structure
IS - 1
ER -