The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders

J. Contreras; L. Hare; B. Camarena; D. Glahn; A. Dassori; R. Medina; S. Contreras; M. Ramirez; R. Armas; R. Munoz; R. Mendoza; H. Raventos; A. Ontiveros; H. Nicolini; R. Palmer; M. Escamilla

doi:10.1111/j.1600-0447.2008.01273.x

The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders

J. Contreras, L. Hare, B. Camarena, D. Glahn, A. Dassori, R. Medina, S. Contreras, M. Ramirez, R. Armas, R. Munoz, R. Mendoza, H. Raventos, A. Ontiveros, H. Nicolini, R. Palmer, M. Escamilla

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families. Results: We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes (P < 0.02, odds ratio 2.18, 95% CI 1.10-4.20). Conclusion: The 'ss' or 'sl' genotype at the 5-HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness.

Original language	English
Pages (from-to)	117-127
Number of pages	11
Journal	Acta Psychiatrica Scandinavica
Volume	119
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0447.2008.01273.x
State	Published - Feb 2009
Externally published	Yes

Keywords

Depression
Psychosis
Serotonin transporter polymorphism

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10.1111/j.1600-0447.2008.01273.x

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Contreras, J., Hare, L., Camarena, B., Glahn, D., Dassori, A., Medina, R., Contreras, S., Ramirez, M., Armas, R., Munoz, R., Mendoza, R., Raventos, H., Ontiveros, A., Nicolini, H., Palmer, R., & Escamilla, M. (2009). The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders. Acta Psychiatrica Scandinavica, 119(2), 117-127. https://doi.org/10.1111/j.1600-0447.2008.01273.x

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title = "The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders",

abstract = "Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families. Results: We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes (P < 0.02, odds ratio 2.18, 95% CI 1.10-4.20). Conclusion: The 'ss' or 'sl' genotype at the 5-HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness.",

keywords = "Depression, Psychosis, Serotonin transporter polymorphism",

author = "J. Contreras and L. Hare and B. Camarena and D. Glahn and A. Dassori and R. Medina and S. Contreras and M. Ramirez and R. Armas and R. Munoz and R. Mendoza and H. Raventos and A. Ontiveros and H. Nicolini and R. Palmer and M. Escamilla",

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Contreras, J, Hare, L, Camarena, B, Glahn, D, Dassori, A, Medina, R, Contreras, S, Ramirez, M, Armas, R, Munoz, R, Mendoza, R, Raventos, H, Ontiveros, A, Nicolini, H, Palmer, R & Escamilla, M 2009, 'The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders', Acta Psychiatrica Scandinavica, vol. 119, no. 2, pp. 117-127. https://doi.org/10.1111/j.1600-0447.2008.01273.x

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AU - Contreras, J.

AU - Hare, L.

AU - Camarena, B.

AU - Glahn, D.

AU - Dassori, A.

AU - Medina, R.

AU - Contreras, S.

AU - Ramirez, M.

AU - Armas, R.

AU - Munoz, R.

AU - Mendoza, R.

AU - Raventos, H.

AU - Ontiveros, A.

AU - Nicolini, H.

AU - Palmer, R.

AU - Escamilla, M.

PY - 2009/2

Y1 - 2009/2

N2 - Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families. Results: We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes (P < 0.02, odds ratio 2.18, 95% CI 1.10-4.20). Conclusion: The 'ss' or 'sl' genotype at the 5-HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness.

AB - Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether genetic variation in 5-HTTLPR, influences current depression, lifetime history of depression and quantitative measures of depression in persons with chronic psychotic disorders. This is an association study of a genetic variant with quantitative and categorical definitions of depression conducted in the southwest US, Mexico and Costa Rica. We analyzed 260 subjects with a history of psychosis, from a sample of 129 families. Results: We found that persons carrying at least one short allele had a statistically significant increased lifetime risk for depressive syndromes (P < 0.02, odds ratio 2.18, 95% CI 1.10-4.20). Conclusion: The 'ss' or 'sl' genotype at the 5-HTTLPR promoter polymorphic locus increases the risk of psychotic individuals to develop major depression during the course of their illness.

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The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders

Abstract

Keywords

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