The sequences of an expressed rat α-tubulin gene and a pseudogene with an inserted repetitive element

Ihor Lemischka, Phillip A. Sharp

Research output: Contribution to journalArticlepeer-review

152 Scopus citations

Abstract

The rat genome contains two segments closely related to a rat α-tubulin mRNA. Both have been cloned and complete nucleotide sequences are presented. Analysis of the structure and sequence of one of these establishes it as a functional α-tubulin gene. The second segment is a processed α-tubulin pseudogene. Comparison of this pseudogene to the mRNA and gene coding for α-tubulin strongly suggests that a mature mRNA was involved in its origin. Features of the pseudogene and a dispersed repetitive element inserted within it possibly reflect a common RNA-mediated process of insertion.

Original languageEnglish
Pages (from-to)330-335
Number of pages6
JournalNature
Volume300
Issue number5890
DOIs
StatePublished - 1982
Externally publishedYes

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