The roles of TET family proteins in development and stem cells

Jihong Yang; Nazym Bashkenova; Ruge Zang; Xin Huang; Jianlong Wang

doi:10.1242/dev.183129

The roles of TET family proteins in development and stem cells

Jihong Yang, Nazym Bashkenova, Ruge Zang, Xin Huang, Jianlong Wang

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Ten-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the demethylation of 5-methylcytosine on DNA. Through global and site-specific demethylation, they regulate cell fate decisions during development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and noncatalytic activities of TETs, and their roles as epigenetic regulators of both DNA and RNA hydroxymethylation, highlighting how TET proteins function in regulating gene expression at both the transcriptional and post-transcriptional levels.

Original language	English
Article number	dev183129
Journal	Development (Cambridge)
Volume	147
Issue number	2
DOIs	https://doi.org/10.1242/dev.183129
State	Published - 2020
Externally published	Yes

Keywords

DNA demethylation
Differentiation
Pluripotency
TET

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abstract = "Ten-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the demethylation of 5-methylcytosine on DNA. Through global and site-specific demethylation, they regulate cell fate decisions during development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and noncatalytic activities of TETs, and their roles as epigenetic regulators of both DNA and RNA hydroxymethylation, highlighting how TET proteins function in regulating gene expression at both the transcriptional and post-transcriptional levels.",

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AU - Yang, Jihong

AU - Bashkenova, Nazym

AU - Zang, Ruge

AU - Huang, Xin

AU - Wang, Jianlong

PY - 2020

Y1 - 2020

N2 - Ten-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the demethylation of 5-methylcytosine on DNA. Through global and site-specific demethylation, they regulate cell fate decisions during development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and noncatalytic activities of TETs, and their roles as epigenetic regulators of both DNA and RNA hydroxymethylation, highlighting how TET proteins function in regulating gene expression at both the transcriptional and post-transcriptional levels.

AB - Ten-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the demethylation of 5-methylcytosine on DNA. Through global and site-specific demethylation, they regulate cell fate decisions during development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and noncatalytic activities of TETs, and their roles as epigenetic regulators of both DNA and RNA hydroxymethylation, highlighting how TET proteins function in regulating gene expression at both the transcriptional and post-transcriptional levels.

KW - DNA demethylation

KW - Differentiation

KW - Pluripotency

KW - TET

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VL - 147

JO - Development (Cambridge)

JF - Development (Cambridge)

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The roles of TET family proteins in development and stem cells

Abstract

Keywords

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