The Role of the Ubiquitin-Proteasome Pathway in the Regulation of the Cellular Hypoxia Response

Koh Nakayama, Ze'ev Ronai

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Changes in oxygen concentration in tissues and cell types govern each of the physiologically important regulatory responses. Key players in the cellular response to altered oxygen concentration include prolyl hydroxylases and the transcription factor HIF1a, both of which are subject to regulation by E3 ubiquitin ligases, Siah and pVHL, respectively. The emerging role of the ubiquitin proteasome pathway in the regulation of cellular hypoxia is discussed.

Original languageEnglish
Title of host publicationProtein Degradation
PublisherWiley - VCH Verlag GmbH & CO. KGaA
Pages132-148
Number of pages17
Volume3
ISBN (Print)9783527318780
DOIs
StatePublished - 14 Dec 2007
Externally publishedYes

Keywords

  • CREB
  • FIH
  • Hypoxia response
  • Hypoxia-inducible Factors
  • Ischemia model
  • MyoD
  • P53/Mdm2
  • PHD
  • Prolyl-hydroxylase Domain-containing Enzymes

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