The role of the endogenous opioid system in the pathogenesis of anxiety disorders

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Abstract

The author suggests that anxiety disorders are related to a deficiency in the endogenous opioid system. The author classifies deficiencies of the endogenous opioid system as congenital or acquired, and also as real or relative. Individuals with 'real deficiency' cannot function adequately in any situations, including situations which are natural for human beings. Persons with 'relative deficiency' are unable to function adequately under circumstances which are unnatural for humans: their 'adaptational reserve' is insufficient. The use of opioid substances and alcohol is a form of self- medication to reduce anxiety. Acupuncture and its variations, psychotherapy, and the administration of placebo can decrease anxiety because these therapeutic maneuvers activate the endogenous opioid system.

Original languageEnglish
Pages (from-to)473-474
Number of pages2
JournalMedical Hypotheses
Volume50
Issue number6
DOIs
StatePublished - Jun 1998
Externally publishedYes

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