The role of shear stress in the pathogenesis of discrete subaortic stenosis: Implications for surgical treatment

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Abstract

Discrete subaortic stenosis (DSS) is characterized by the presence of an obstructing membrane in the left ventricular outflow tract (LVOT). Evidence suggests that the formation of DSS represents a fibroproliferative reaction of the endocardium occurring in response to alterations in shear stress caused by geometric abnormalities within the LVOT. The aim of this review is to discuss the role of altered LVOT shear stress in the pathogenesis of DSS, and its implications in surgical decision making.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Heart Valve Disease
Volume20
Issue number2
StatePublished - Mar 2011

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