TY - CHAP
T1 - The Role of Serotonin in the Regulation of Anxiety
AU - Kahn, Rene S.
AU - Kalus, Oren
AU - Wetzler, Scott
AU - Van Praag, Herman M.
N1 - Publisher Copyright:
© 1991 by Albert Einstein College of Medicine of Yeshiva University.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - This chapter reviews research relating 5-HT to another dimension of psychopathology: anxiety. Since 1948, when it was discovered in blood platelets, serotonin (5-HT) has gained increasing attention for its role in a variety of brain functions, mental disorders. In comparison with studies of 5-HT in depression, the role of 5-HT in anxiety has received considerably less attention. Most of the data supporting connection between 5-HT, anxiety are based on animal studies. A major methodological problem in animal laboratory studies of anxiety is that the emotion must be inferred exclusively from external behavior. Assessment of DHT’s effects at times other than the ones used in the above studies has led to varying findings. Since diminishing 5-HT function results in anxiety reduction, one might predict that increasing 5-HT availability would cause the opposite effect. Since BZs are clearly effective anxiety-reducing agents in humans, cause release from behavioral suppression in animals, it would be of interest to determine their effects on central 5-HT.
AB - This chapter reviews research relating 5-HT to another dimension of psychopathology: anxiety. Since 1948, when it was discovered in blood platelets, serotonin (5-HT) has gained increasing attention for its role in a variety of brain functions, mental disorders. In comparison with studies of 5-HT in depression, the role of 5-HT in anxiety has received considerably less attention. Most of the data supporting connection between 5-HT, anxiety are based on animal studies. A major methodological problem in animal laboratory studies of anxiety is that the emotion must be inferred exclusively from external behavior. Assessment of DHT’s effects at times other than the ones used in the above studies has led to varying findings. Since diminishing 5-HT function results in anxiety reduction, one might predict that increasing 5-HT availability would cause the opposite effect. Since BZs are clearly effective anxiety-reducing agents in humans, cause release from behavioral suppression in animals, it would be of interest to determine their effects on central 5-HT.
UR - https://www.scopus.com/pages/publications/85160488587
U2 - 10.4324/9781315825861-6
DO - 10.4324/9781315825861-6
M3 - Chapter
AN - SCOPUS:85160488587
SN - 9780876305898
SP - 129
EP - 160
BT - The Role of Serotonin in Psychiatric Disorders
PB - Taylor and Francis
ER -