The role of RhoA in tissue polarity and frizzled signalling

David I. Strutt, Ursula Weber, Marek Mlodzik

Research output: Contribution to journalArticlepeer-review

479 Scopus citations


The tissue polarity genes of Drosophila are required for correct establishment of planar polarity in epidermal structures, which in the eye is shown in the mirror-image symmetric arrangement of ommatidia relative to the dorsoventral midline. Mutations in the genes frizzled (fz), dishevelled (dsh) and prickle-spiny-legs (pk-sple) result in the loss of this mirror-image symmetry. fz encodes a serpentine receptor-like transmembrane protein required for reception and transmission of a polarity signal. Little else is known of the signalling pathway(s) involved other than that Dsh acts downstream of Fz. We have identified mutations in the Drosophila homologue of RhoA p21 GTPase, and by analysis of their phenotype show that RhoA is required for the generation of tissue polarity. Genetic interactions indicate a role for RhoA in signalling mediated by Fz and Dsh, and furthermore suggest that JNK/SAPK-like kinases are involved. These data are consistent with a Fz/RhoA signalling cascade analogous to the yeast pheromone signalling pathway and that proposed for activation of the serum response factor (SRF) in vertebrate cells.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
Issue number6630
StatePublished - 15 May 1997
Externally publishedYes


Dive into the research topics of 'The role of RhoA in tissue polarity and frizzled signalling'. Together they form a unique fingerprint.

Cite this