The role of radiation in improving survival for early-stage carcinosarcoma and leiomyosarcoma

Jason D. Wright, Venkatraman E. Seshan, Monjri Shah, Peter B. Schiff, William M. Burke, Carmel J. Cohen, Thomas J. Herzog

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Objective: We examined the effect of radiation on survival for early-stage uterine carcinosarcomas and leiomyosarcomas. Study Design: The surveillance, epidemiology, and end results database was used to identify patients with stage I/II carcinosarcomas and leiomyosarcomas. Logistic regression and Cox models were developed to determine radiation use and survival. Results: Among 1819 women with carcinosarcomas and 1088 women with leiomyosarcomas, radiation was administered to 667 of the patients (37%) with carcinosarcomas and to 235 of the patients (22%) with leiomyosarcomas. In a multivariate model, adjuvant radiation reduced the risk of death by 21% in women with carcinosarcomas (hazard ratio, 0.79; 95% CI, 0.7-0.9). Radiation reduced mortality rates in patients with carcinosarcomas who had not undergone node dissection but had only a marginal effect on survival in node-negative women. Adjuvant radiation had no effect on survival for early-stage leiomyosarcomas (hazard ratio, 1.1; 95% CI, 0.9-1.4). Conclusion: Adjuvant radiotherapy improves survival for select patients with early-stage carcinosarcomas but is of limited value for leiomyosarcomas.

Original languageEnglish
Pages (from-to)536.e1-536.e8
JournalAmerican Journal of Obstetrics and Gynecology
Volume199
Issue number5
DOIs
StatePublished - Nov 2008
Externally publishedYes

Keywords

  • carcinosarcoma
  • leiomyosarcoma
  • radiation
  • uterine sarcoma

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