The role of NrCAM in neural development and disorders-Beyond a simple glue in the brain

Takeshi Sakurai

doi:10.1016/j.mcn.2011.12.002

The role of NrCAM in neural development and disorders-Beyond a simple glue in the brain

Takeshi Sakurai

Research output: Contribution to journal › Review article › peer-review

105 Scopus citations

Abstract

NrCAM is a neuronal cell adhesion molecule of the L1 family of immunoglobulin super family. It plays a wide variety of roles in neural development, including cell proliferation and differentiation, axon growth and guidance, synapse formation, and the formation of the myelinated nerve structure. NrCAM functions in cell adhesion and modulates signaling pathways in neural development through multiple molecular interactions with guidance and other factors. Alterations in NrCAM structure/expression are associated with psychiatric disorders such as autism and drug addiction and with tumor progression. The mechanisms of NrCAM participation in development and how these might be perturbed in disorders are reviewed.

Original language	English
Pages (from-to)	351-363
Number of pages	13
Journal	Molecular and Cellular Neuroscience
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/j.mcn.2011.12.002
State	Published - Mar 2012
Externally published	Yes

Keywords

Axon growth
Axon guidance
Cancer progression
Cell adhesion molecules
Psychiatric disorders
Synapse formation

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10.1016/j.mcn.2011.12.002

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title = "The role of NrCAM in neural development and disorders-Beyond a simple glue in the brain",

abstract = "NrCAM is a neuronal cell adhesion molecule of the L1 family of immunoglobulin super family. It plays a wide variety of roles in neural development, including cell proliferation and differentiation, axon growth and guidance, synapse formation, and the formation of the myelinated nerve structure. NrCAM functions in cell adhesion and modulates signaling pathways in neural development through multiple molecular interactions with guidance and other factors. Alterations in NrCAM structure/expression are associated with psychiatric disorders such as autism and drug addiction and with tumor progression. The mechanisms of NrCAM participation in development and how these might be perturbed in disorders are reviewed.",

keywords = "Axon growth, Axon guidance, Cancer progression, Cell adhesion molecules, Psychiatric disorders, Synapse formation",

author = "Takeshi Sakurai",

note = "Funding Information: I thank Drs. Carol Mason, Tim Petros, Andy Furley, Julia Kaltschmidt, James Salzer, Avri Ben-Ze'ev, Akira Sawa, and anonymous reviewers for critical reading and thoughtful comments on the manuscript. I also thank Ms. Asako Uto and Yukiko Lema for help with preparation of the manuscript. My research was supported partly by Seaver Autism Center and NIH (Carol Mason and David Colman). I would like to dedicate this to late Dr. David R. Colman (1949–2011) who once said in a casual conversation, “Science is like the myth of Ariadne's thread and the Minotaur's labyrinth. We know where it will begin, but we don't know where it will end”. ",

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AB - NrCAM is a neuronal cell adhesion molecule of the L1 family of immunoglobulin super family. It plays a wide variety of roles in neural development, including cell proliferation and differentiation, axon growth and guidance, synapse formation, and the formation of the myelinated nerve structure. NrCAM functions in cell adhesion and modulates signaling pathways in neural development through multiple molecular interactions with guidance and other factors. Alterations in NrCAM structure/expression are associated with psychiatric disorders such as autism and drug addiction and with tumor progression. The mechanisms of NrCAM participation in development and how these might be perturbed in disorders are reviewed.

KW - Axon growth

KW - Axon guidance

KW - Cancer progression

KW - Cell adhesion molecules

KW - Psychiatric disorders

KW - Synapse formation

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EP - 363

JO - Molecular and Cellular Neuroscience

JF - Molecular and Cellular Neuroscience

IS - 3

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The role of NrCAM in neural development and disorders-Beyond a simple glue in the brain

Abstract

Keywords

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