The role of NrCAM in neural development and disorders-Beyond a simple glue in the brain

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Abstract

NrCAM is a neuronal cell adhesion molecule of the L1 family of immunoglobulin super family. It plays a wide variety of roles in neural development, including cell proliferation and differentiation, axon growth and guidance, synapse formation, and the formation of the myelinated nerve structure. NrCAM functions in cell adhesion and modulates signaling pathways in neural development through multiple molecular interactions with guidance and other factors. Alterations in NrCAM structure/expression are associated with psychiatric disorders such as autism and drug addiction and with tumor progression. The mechanisms of NrCAM participation in development and how these might be perturbed in disorders are reviewed.

Original languageEnglish
Pages (from-to)351-363
Number of pages13
JournalMolecular and Cellular Neuroscience
Volume49
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • Axon growth
  • Axon guidance
  • Cancer progression
  • Cell adhesion molecules
  • Psychiatric disorders
  • Synapse formation

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