The role of naïve T-cells in HIV-1 pathogenesis: An emerging key player

Gabriela Khoury; Reena Rajasuriar; Paul U. Cameron; Sharon R. Lewin

doi:10.1016/j.clim.2011.09.002

The role of naïve T-cells in HIV-1 pathogenesis: An emerging key player

Gabriela Khoury, Reena Rajasuriar, Paul U. Cameron, Sharon R. Lewin

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Functional naïve T-cells are critical for an effective immune response to multiple pathogens. HIV leads to a significant reduction in CD4+ naïve T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART). Here we review the basic homeostatic mechanisms that maintain naïve CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naïve CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naïve CD4+ T-cells.

Original language	English
Pages (from-to)	253-267
Number of pages	15
Journal	Clinical Immunology
Volume	141
Issue number	3
DOIs	https://doi.org/10.1016/j.clim.2011.09.002
State	Published - Dec 2011
Externally published	Yes

Keywords

Antiretroviral therapy;
HIV-1;
IL-7;
Immune reconstitution;
Naïve T-cells;
Reservoirs

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10.1016/j.clim.2011.09.002

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title = "The role of na{\"i}ve T-cells in HIV-1 pathogenesis: An emerging key player",

abstract = "Functional na{\"i}ve T-cells are critical for an effective immune response to multiple pathogens. HIV leads to a significant reduction in CD4+ na{\"i}ve T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART). Here we review the basic homeostatic mechanisms that maintain na{\"i}ve CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on na{\"i}ve CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of na{\"i}ve CD4+ T-cells.",

keywords = "Antiretroviral therapy;, HIV-1;, IL-7;, Immune reconstitution;, Na{\"i}ve T-cells;, Reservoirs",

author = "Gabriela Khoury and Reena Rajasuriar and Cameron, {Paul U.} and Lewin, {Sharon R.}",

note = "Funding Information: S.R.L is funded by the NHMRC and Alfred Foundation and is an NHMRC Practitioner Fellow ",

year = "2011",

month = dec,

doi = "10.1016/j.clim.2011.09.002",

language = "English",

volume = "141",

pages = "253--267",

journal = "Clinical Immunology",

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T1 - The role of naïve T-cells in HIV-1 pathogenesis

T2 - An emerging key player

AU - Khoury, Gabriela

AU - Rajasuriar, Reena

AU - Cameron, Paul U.

AU - Lewin, Sharon R.

N1 - Funding Information: S.R.L is funded by the NHMRC and Alfred Foundation and is an NHMRC Practitioner Fellow

PY - 2011/12

Y1 - 2011/12

N2 - Functional naïve T-cells are critical for an effective immune response to multiple pathogens. HIV leads to a significant reduction in CD4+ naïve T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART). Here we review the basic homeostatic mechanisms that maintain naïve CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naïve CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naïve CD4+ T-cells.

AB - Functional naïve T-cells are critical for an effective immune response to multiple pathogens. HIV leads to a significant reduction in CD4+ naïve T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART). Here we review the basic homeostatic mechanisms that maintain naïve CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naïve CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naïve CD4+ T-cells.

KW - Antiretroviral therapy;

KW - HIV-1;

KW - IL-7;

KW - Immune reconstitution;

KW - Naïve T-cells;

KW - Reservoirs

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DO - 10.1016/j.clim.2011.09.002

M3 - Review article

C2 - 21996455

AN - SCOPUS:81355127448

SN - 1521-6616

VL - 141

SP - 253

EP - 267

JO - Clinical Immunology

JF - Clinical Immunology

IS - 3

ER -

The role of naïve T-cells in HIV-1 pathogenesis: An emerging key player

Abstract

Keywords

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