The Role of Megakaryocytes in Myelofibrosis

Johanna Melo-Cardenas; Anna Rita Migliaccio; John D. Crispino

doi:10.1016/j.hoc.2020.11.004

The Role of Megakaryocytes in Myelofibrosis

Johanna Melo-Cardenas
, Anna Rita Migliaccio
, John D. Crispino

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Megakaryocytes give rise to platelets, which have a wide variety of functions in coagulation, immune response, inflammation, and tissue repair. Dysregulation of megakaryocytes is a key feature of in the myeloproliferative neoplasms, especially myelofibrosis. Megakaryocytes are among the main drivers of myelofibrosis by promoting myeloproliferation and bone marrow fibrosis. In vivo targeting of megakaryocytes by genetic and pharmacologic approaches ameliorates the disease, underscoring the important role of megakaryocytes in myeloproliferative neoplasms.

Original language	English
Pages (from-to)	191-203
Number of pages	13
Journal	Hematology/Oncology Clinics of North America
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/j.hoc.2020.11.004
State	Published - Apr 2021
Externally published	Yes

Keywords

JAK/STAT
Megakaryocyte
Myeloproliferative neoplasms

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@article{a2f79bb03d2c4b919da890289697febc,

title = "The Role of Megakaryocytes in Myelofibrosis",

abstract = "Megakaryocytes give rise to platelets, which have a wide variety of functions in coagulation, immune response, inflammation, and tissue repair. Dysregulation of megakaryocytes is a key feature of in the myeloproliferative neoplasms, especially myelofibrosis. Megakaryocytes are among the main drivers of myelofibrosis by promoting myeloproliferation and bone marrow fibrosis. In vivo targeting of megakaryocytes by genetic and pharmacologic approaches ameliorates the disease, underscoring the important role of megakaryocytes in myeloproliferative neoplasms.",

keywords = "JAK/STAT, Megakaryocyte, Myeloproliferative neoplasms",

author = "Johanna Melo-Cardenas and Migliaccio, \{Anna Rita\} and Crispino, \{John D.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = apr,

doi = "10.1016/j.hoc.2020.11.004",

language = "English",

volume = "35",

pages = "191--203",

journal = "Hematology/Oncology Clinics of North America",

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T1 - The Role of Megakaryocytes in Myelofibrosis

AU - Melo-Cardenas, Johanna

AU - Migliaccio, Anna Rita

AU - Crispino, John D.

PY - 2021/4

Y1 - 2021/4

N2 - Megakaryocytes give rise to platelets, which have a wide variety of functions in coagulation, immune response, inflammation, and tissue repair. Dysregulation of megakaryocytes is a key feature of in the myeloproliferative neoplasms, especially myelofibrosis. Megakaryocytes are among the main drivers of myelofibrosis by promoting myeloproliferation and bone marrow fibrosis. In vivo targeting of megakaryocytes by genetic and pharmacologic approaches ameliorates the disease, underscoring the important role of megakaryocytes in myeloproliferative neoplasms.

AB - Megakaryocytes give rise to platelets, which have a wide variety of functions in coagulation, immune response, inflammation, and tissue repair. Dysregulation of megakaryocytes is a key feature of in the myeloproliferative neoplasms, especially myelofibrosis. Megakaryocytes are among the main drivers of myelofibrosis by promoting myeloproliferation and bone marrow fibrosis. In vivo targeting of megakaryocytes by genetic and pharmacologic approaches ameliorates the disease, underscoring the important role of megakaryocytes in myeloproliferative neoplasms.

KW - JAK/STAT

KW - Megakaryocyte

KW - Myeloproliferative neoplasms

UR - https://www.scopus.com/pages/publications/85099273212

U2 - 10.1016/j.hoc.2020.11.004

DO - 10.1016/j.hoc.2020.11.004

M3 - Review article

C2 - 33641863

AN - SCOPUS:85099273212

SN - 0889-8588

VL - 35

SP - 191

EP - 203

JO - Hematology/Oncology Clinics of North America

JF - Hematology/Oncology Clinics of North America

IS - 2

ER -

The Role of Megakaryocytes in Myelofibrosis

Abstract

Keywords

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