The role of LTBPs in TGF beta signaling

Daniel Rifkin, Nalani Sachan, Karan Singh, Elyse Sauber, George Tellides, Francesco Ramirez

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function.

Original languageEnglish
Pages (from-to)95-104
Number of pages10
JournalDevelopmental Dynamics
Issue number1
StatePublished - Jan 2022


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