The role of LTBPs in TGF beta signaling

Daniel Rifkin; Nalani Sachan; Karan Singh; Elyse Sauber; George Tellides; Francesco Ramirez

doi:10.1002/dvdy.331

The role of LTBPs in TGF beta signaling

Daniel Rifkin, Nalani Sachan, Karan Singh, Elyse Sauber, George Tellides, Francesco Ramirez

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function.

Original language	English
Pages (from-to)	95-104
Number of pages	10
Journal	Developmental Dynamics
Volume	251
Issue number	1
DOIs	https://doi.org/10.1002/dvdy.331
State	Published - Jan 2022

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10.1002/dvdy.331

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abstract = "The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function.",

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AU - Tellides, George

AU - Ramirez, Francesco

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AB - The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function.

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The role of LTBPs in TGF beta signaling

Abstract

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