TY - JOUR
T1 - The role of lactate-mediated metabolic coupling between astrocytes and neurons in long-term memory formation
AU - Steinman, Michael Q.
AU - Gao, Virginia
AU - Alberini, Cristina M.
N1 - Publisher Copyright:
© 2016 Steinman, Gao and Alberini.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - Long-term memory formation, the ability to retain information over time about an experience, is a complex function that affects multiple behaviors, and is an integral part of an individual’s identity. In the last 50 years many scientists have focused their work on understanding the biological mechanisms underlying memory formation and processing. Molecular studies over the last three decades have mostly investigated, or given attention to, neuronal mechanisms. However, the brain is composed of different cell types that, by concerted actions, cooperate to mediate brain functions. Here, we consider some new insights that emerged from recent studies implicating astrocytic glycogen and glucose metabolisms, and particularly their coupling to neuronal functions via lactate, as an essential mechanism for long-term memory formation.
AB - Long-term memory formation, the ability to retain information over time about an experience, is a complex function that affects multiple behaviors, and is an integral part of an individual’s identity. In the last 50 years many scientists have focused their work on understanding the biological mechanisms underlying memory formation and processing. Molecular studies over the last three decades have mostly investigated, or given attention to, neuronal mechanisms. However, the brain is composed of different cell types that, by concerted actions, cooperate to mediate brain functions. Here, we consider some new insights that emerged from recent studies implicating astrocytic glycogen and glucose metabolisms, and particularly their coupling to neuronal functions via lactate, as an essential mechanism for long-term memory formation.
KW - Astrocyte
KW - Glucose
KW - Glucose metabolism
KW - Lactate
KW - Learning
KW - Memory
KW - Neuron
UR - http://www.scopus.com/inward/record.url?scp=84961714969&partnerID=8YFLogxK
U2 - 10.3389/fnint.2016.00010
DO - 10.3389/fnint.2016.00010
M3 - Review article
AN - SCOPUS:84961714969
SN - 1662-5145
VL - 10
JO - Frontiers in Integrative Neuroscience
JF - Frontiers in Integrative Neuroscience
IS - MAR2016
M1 - 10
ER -