The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating

Lingxuan Chen, Kirstie A. Cummings, William Mau, Yosif Zaki, Zhe Dong, Sima Rabinowitz, Roger L. Clem, Tristan Shuman, Denise J. Cai

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Memory is a dynamic process that is continuously regulated by both synaptic and intrinsic neural mechanisms. While numerous studies have shown that synaptic plasticity is important in various types and phases of learning and memory, neuronal intrinsic excitability has received relatively less attention, especially regarding the dynamic nature of memory. In this review, we present evidence demonstrating the importance of intrinsic excitability in memory allocation, consolidation, and updating. We also consider the intricate interaction between intrinsic excitability and synaptic plasticity in shaping memory, supporting both memory stability and flexibility.

Original languageEnglish
Article number107266
JournalNeurobiology of Learning and Memory
Volume173
DOIs
StatePublished - Sep 2020

Keywords

  • Intrinsic excitability
  • Memory allocation
  • Memory consolidation
  • Memory updating
  • Synaptic plasticity
  • Temporal memory-linking

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