The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating

Lingxuan Chen; Kirstie A. Cummings; William Mau; Yosif Zaki; Zhe Dong; Sima Rabinowitz; Roger L. Clem; Tristan Shuman; Denise J. Cai

doi:10.1016/j.nlm.2020.107266

The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating

Lingxuan Chen, Kirstie A. Cummings, William Mau, Yosif Zaki, Zhe Dong, Sima Rabinowitz, Roger L. Clem, Tristan Shuman, Denise J. Cai

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Memory is a dynamic process that is continuously regulated by both synaptic and intrinsic neural mechanisms. While numerous studies have shown that synaptic plasticity is important in various types and phases of learning and memory, neuronal intrinsic excitability has received relatively less attention, especially regarding the dynamic nature of memory. In this review, we present evidence demonstrating the importance of intrinsic excitability in memory allocation, consolidation, and updating. We also consider the intricate interaction between intrinsic excitability and synaptic plasticity in shaping memory, supporting both memory stability and flexibility.

Original language	English
Article number	107266
Journal	Neurobiology of Learning and Memory
Volume	173
DOIs	https://doi.org/10.1016/j.nlm.2020.107266
State	Published - Sep 2020

Keywords

Intrinsic excitability
Memory allocation
Memory consolidation
Memory updating
Synaptic plasticity
Temporal memory-linking

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10.1016/j.nlm.2020.107266

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abstract = "Memory is a dynamic process that is continuously regulated by both synaptic and intrinsic neural mechanisms. While numerous studies have shown that synaptic plasticity is important in various types and phases of learning and memory, neuronal intrinsic excitability has received relatively less attention, especially regarding the dynamic nature of memory. In this review, we present evidence demonstrating the importance of intrinsic excitability in memory allocation, consolidation, and updating. We also consider the intricate interaction between intrinsic excitability and synaptic plasticity in shaping memory, supporting both memory stability and flexibility.",

keywords = "Intrinsic excitability, Memory allocation, Memory consolidation, Memory updating, Synaptic plasticity, Temporal memory-linking",

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AU - Chen, Lingxuan

AU - Cummings, Kirstie A.

AU - Mau, William

AU - Zaki, Yosif

AU - Dong, Zhe

AU - Rabinowitz, Sima

AU - Clem, Roger L.

AU - Shuman, Tristan

AU - Cai, Denise J.

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AB - Memory is a dynamic process that is continuously regulated by both synaptic and intrinsic neural mechanisms. While numerous studies have shown that synaptic plasticity is important in various types and phases of learning and memory, neuronal intrinsic excitability has received relatively less attention, especially regarding the dynamic nature of memory. In this review, we present evidence demonstrating the importance of intrinsic excitability in memory allocation, consolidation, and updating. We also consider the intricate interaction between intrinsic excitability and synaptic plasticity in shaping memory, supporting both memory stability and flexibility.

KW - Intrinsic excitability

KW - Memory allocation

KW - Memory consolidation

KW - Memory updating

KW - Synaptic plasticity

KW - Temporal memory-linking

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JO - Neurobiology of Learning and Memory

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ER -

The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating

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Keywords

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