The role of inflammation and infection in preterm birth

Jamie A. Bastek, Luis M. Gómez, Michal A. Elovitz

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations

Abstract

Much emphasis in recent decades has been devoted to inflammation and infection as a premier causal mechanism of preterm birth. This article explores the epidemiologic, clinical, and animal data that exist to support this conceptual paradigm as well as proposed mechanisms through which to potentially mitigate the adversity of prematurity. Truly successful interventions are not likely to occur until the pathogenesis of preterm birth and the role of inflammation in causing not only parturition but also fetal and neonatal injury is fully elucidated.

Original languageEnglish
Pages (from-to)385-406
Number of pages22
JournalClinics in Perinatology
Volume38
Issue number3
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • Animal model
  • Biomarkers
  • Infection
  • Inflammation
  • Preterm birth

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