The role of inflammation and immunity in the pathogenesis of liver fibrosis

Wajahat Z. Mehal; Scott L. Friedman

doi:10.1007/978-1-59745-518-3_10

The role of inflammation and immunity in the pathogenesis of liver fibrosis

Wajahat Z. Mehal, Scott L. Friedman

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

9 Scopus citations

Abstract

Hepatic fibrosis represents a ubiquitous response of the liver to acute or chronic injury. Tremendous progress in understanding the pathophysiology of this wound-healing response has led to realistic expectations for treating fibrosis in patients with chronic liver disease owing to either viral hepatitis or metabolic or autoimmune diseases, among others. There has been continued clarification of the cellular source of extracellular matrix (ECM) in hepatic fibrosis, major advances in understanding signaling and transcriptional events, and exciting insights into the biology of fibrosis progression and resolution (see refs. 1-4 and references therein for more general reviews).

Original language	English
Title of host publication	Liver Immunology
Subtitle of host publication	Principles and Practice
Publisher	Humana Press
Pages	111-121
Number of pages	11
ISBN (Print)	9781588298188
DOIs	https://doi.org/10.1007/978-1-59745-518-3_10
State	Published - 2007

Access to Document

10.1007/978-1-59745-518-3_10

Cite this

@inbook{d4d8f613e2c44012bb30dbce670cd6d9,

title = "The role of inflammation and immunity in the pathogenesis of liver fibrosis",

abstract = "Hepatic fibrosis represents a ubiquitous response of the liver to acute or chronic injury. Tremendous progress in understanding the pathophysiology of this wound-healing response has led to realistic expectations for treating fibrosis in patients with chronic liver disease owing to either viral hepatitis or metabolic or autoimmune diseases, among others. There has been continued clarification of the cellular source of extracellular matrix (ECM) in hepatic fibrosis, major advances in understanding signaling and transcriptional events, and exciting insights into the biology of fibrosis progression and resolution (see refs. 1-4 and references therein for more general reviews).",

author = "Mehal, {Wajahat Z.} and Friedman, {Scott L.}",

year = "2007",

doi = "10.1007/978-1-59745-518-3_10",

language = "English",

isbn = "9781588298188",

pages = "111--121",

booktitle = "Liver Immunology",

publisher = "Humana Press",

address = "United States",

}

TY - CHAP

T1 - The role of inflammation and immunity in the pathogenesis of liver fibrosis

AU - Mehal, Wajahat Z.

AU - Friedman, Scott L.

PY - 2007

Y1 - 2007

N2 - Hepatic fibrosis represents a ubiquitous response of the liver to acute or chronic injury. Tremendous progress in understanding the pathophysiology of this wound-healing response has led to realistic expectations for treating fibrosis in patients with chronic liver disease owing to either viral hepatitis or metabolic or autoimmune diseases, among others. There has been continued clarification of the cellular source of extracellular matrix (ECM) in hepatic fibrosis, major advances in understanding signaling and transcriptional events, and exciting insights into the biology of fibrosis progression and resolution (see refs. 1-4 and references therein for more general reviews).

AB - Hepatic fibrosis represents a ubiquitous response of the liver to acute or chronic injury. Tremendous progress in understanding the pathophysiology of this wound-healing response has led to realistic expectations for treating fibrosis in patients with chronic liver disease owing to either viral hepatitis or metabolic or autoimmune diseases, among others. There has been continued clarification of the cellular source of extracellular matrix (ECM) in hepatic fibrosis, major advances in understanding signaling and transcriptional events, and exciting insights into the biology of fibrosis progression and resolution (see refs. 1-4 and references therein for more general reviews).

UR - http://www.scopus.com/inward/record.url?scp=84889992232&partnerID=8YFLogxK

U2 - 10.1007/978-1-59745-518-3_10

DO - 10.1007/978-1-59745-518-3_10

M3 - Chapter

AN - SCOPUS:84889992232

SN - 9781588298188

SP - 111

EP - 121

BT - Liver Immunology

PB - Humana Press

ER -

The role of inflammation and immunity in the pathogenesis of liver fibrosis

Abstract

Access to Document

Fingerprint

Cite this