The role of growth hormone receptor in β cell function

Shuang Wang; Jin Wu; Ning Wang; Li Zeng; Yingjie Wu

doi:10.1016/j.ghir.2017.08.002

The role of growth hormone receptor in β cell function

Shuang Wang, Jin Wu, Ning Wang, Li Zeng, Yingjie Wu

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Growth hormone (GH) exerts numerous effects on tissues through binding to its receptor, GHR, which resides on cell membranes in many different organs and tissues. Endocrine pancreatic β cells are the only source of insulin secretion in response to metabolic demand, thereby regulating blood glucose and maintaining metabolic homeostasis. β cell dysfunction is the main composition of diabetes mellitus. Numerous studies have provided strong evidence that GHR signaling plays an independent role in β cell function. In this review, we focus on the role of GHR signaling in β cell actions and the underlying molecular mechanisms.

Original language	English
Pages (from-to)	30-35
Number of pages	6
Journal	Growth Hormone and IGF Research
Volume	36
DOIs	https://doi.org/10.1016/j.ghir.2017.08.002
State	Published - Oct 2017
Externally published	Yes

Keywords

Diabetes
GHR signaling
Growth hormone receptor
β cell function

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10.1016/j.ghir.2017.08.002

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title = "The role of growth hormone receptor in β cell function",

abstract = "Growth hormone (GH) exerts numerous effects on tissues through binding to its receptor, GHR, which resides on cell membranes in many different organs and tissues. Endocrine pancreatic β cells are the only source of insulin secretion in response to metabolic demand, thereby regulating blood glucose and maintaining metabolic homeostasis. β cell dysfunction is the main composition of diabetes mellitus. Numerous studies have provided strong evidence that GHR signaling plays an independent role in β cell function. In this review, we focus on the role of GHR signaling in β cell actions and the underlying molecular mechanisms.",

keywords = "Diabetes, GHR signaling, Growth hormone receptor, β cell function",

author = "Shuang Wang and Jin Wu and Ning Wang and Li Zeng and Yingjie Wu",

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doi = "10.1016/j.ghir.2017.08.002",

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T1 - The role of growth hormone receptor in β cell function

AU - Wang, Shuang

AU - Wu, Jin

AU - Wang, Ning

AU - Zeng, Li

AU - Wu, Yingjie

PY - 2017/10

Y1 - 2017/10

N2 - Growth hormone (GH) exerts numerous effects on tissues through binding to its receptor, GHR, which resides on cell membranes in many different organs and tissues. Endocrine pancreatic β cells are the only source of insulin secretion in response to metabolic demand, thereby regulating blood glucose and maintaining metabolic homeostasis. β cell dysfunction is the main composition of diabetes mellitus. Numerous studies have provided strong evidence that GHR signaling plays an independent role in β cell function. In this review, we focus on the role of GHR signaling in β cell actions and the underlying molecular mechanisms.

AB - Growth hormone (GH) exerts numerous effects on tissues through binding to its receptor, GHR, which resides on cell membranes in many different organs and tissues. Endocrine pancreatic β cells are the only source of insulin secretion in response to metabolic demand, thereby regulating blood glucose and maintaining metabolic homeostasis. β cell dysfunction is the main composition of diabetes mellitus. Numerous studies have provided strong evidence that GHR signaling plays an independent role in β cell function. In this review, we focus on the role of GHR signaling in β cell actions and the underlying molecular mechanisms.

KW - Diabetes

KW - GHR signaling

KW - Growth hormone receptor

KW - β cell function

UR - https://www.scopus.com/pages/publications/85029184015

U2 - 10.1016/j.ghir.2017.08.002

DO - 10.1016/j.ghir.2017.08.002

M3 - Review article

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AN - SCOPUS:85029184015

SN - 1096-6374

VL - 36

SP - 30

EP - 35

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

ER -

The role of growth hormone receptor in β cell function

Abstract

Keywords

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