The role of growth hormone receptor in β cell function

Shuang Wang, Jin Wu, Ning Wang, Li Zeng, Yingjie Wu

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Growth hormone (GH) exerts numerous effects on tissues through binding to its receptor, GHR, which resides on cell membranes in many different organs and tissues. Endocrine pancreatic β cells are the only source of insulin secretion in response to metabolic demand, thereby regulating blood glucose and maintaining metabolic homeostasis. β cell dysfunction is the main composition of diabetes mellitus. Numerous studies have provided strong evidence that GHR signaling plays an independent role in β cell function. In this review, we focus on the role of GHR signaling in β cell actions and the underlying molecular mechanisms.

Original languageEnglish
Pages (from-to)30-35
Number of pages6
JournalGrowth Hormone and IGF Research
Volume36
DOIs
StatePublished - Oct 2017
Externally publishedYes

Keywords

  • Diabetes
  • GHR signaling
  • Growth hormone receptor
  • β cell function

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