The role of epigenetic mediation and the future of food allergy research

Christine Quake, Kari C. Nadeau

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

IgE-mediated food allergy is a developing global health problem with prevalence rising at alarmingly fast rates. In this review, we discuss the interplay between genetics, epigenetics, and environmental exposures in the pathogenesis of food allergies. We aim to highlight the most recent evidence that suggests how epigenetic control may mediate genetic susceptibility of food allergies. We also examine how epigenetic modifications may be the key in explaining how environmental factors modulate and modify gene expression, leading to the dysregulation of immune tolerance and consequently, the development of food allergies. The emerging epigenetic paradigm in food allergies is likely to provide new mechanistic insight into food allergy risk and development as well as shape our therapeutic and preventive strategies.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume43
DOIs
StatePublished - Jul 2015
Externally publishedYes

Keywords

  • Early exposure
  • Environmental factors
  • Epigenetics
  • Food allergies
  • Immune tolerance
  • Immunotherapy

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