TY - JOUR
T1 - The role of enhancers as centres for general transcription factor recruitment
AU - Szutorisz, Henrietta
AU - Dillon, Niall
AU - Tora, László
N1 - Funding Information:
We thank Cheok-Man Chow for useful comments on the manuscript and Ferenc Müller for helpful discussion. H.S. is funded by an EU Marie Curie Intra-European Fellowship. Our research is supported by funding from the Medical Research Council, UK and the Leukaemia Research Fund to N.D., by grants from INSERM, CNRS, Hôpital Universitaire de Strasbourg, Association pour la Recherche sur le Cancer, the Fondation pour la Recherche Médicale, the Font Nationale de La Science ACI, EU STREP (LSHG-CT-2004–502950) and AICR (03–084) to L.T., and European Community RTN (HPRN-CT 00504228) to L.T. and N.D.
PY - 2005/11
Y1 - 2005/11
N2 - Activation of eukaryotic genes requires a tight temporal control of trans-acting-factor binding to different types of sequence elements. General transcription factors (GTFs) have a central role in the regulation of RNA polymerase II (Pol II) function because they are involved in the initiation of transcription at all class II promoters. Recent studies have shown that GTFs and Pol II are recruited to enhancer elements and that this binding is an early event in gene activation. We propose that an important role of some enhancers is to function as nucleation centres for the assembly of the pre-initiation complex to regulate the timing of gene activation during development, differentiation and the cell cycle.
AB - Activation of eukaryotic genes requires a tight temporal control of trans-acting-factor binding to different types of sequence elements. General transcription factors (GTFs) have a central role in the regulation of RNA polymerase II (Pol II) function because they are involved in the initiation of transcription at all class II promoters. Recent studies have shown that GTFs and Pol II are recruited to enhancer elements and that this binding is an early event in gene activation. We propose that an important role of some enhancers is to function as nucleation centres for the assembly of the pre-initiation complex to regulate the timing of gene activation during development, differentiation and the cell cycle.
UR - http://www.scopus.com/inward/record.url?scp=27544466462&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2005.08.006
DO - 10.1016/j.tibs.2005.08.006
M3 - Article
C2 - 16126390
AN - SCOPUS:27544466462
SN - 0968-0004
VL - 30
SP - 593
EP - 599
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 11
ER -