The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma

Aashiyana F. Koreishi; Adam J. Saenz; Dan O. Persky; Hayan Cui; Allison Moskowitz; Craig H. Moskowitz; Julie Teruya-Feldstein

doi:10.1097/PAI.0b013e3181c7138b

The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma

Aashiyana F. Koreishi, Adam J. Saenz, Dan O. Persky, Hayan Cui, Allison Moskowitz, Craig H. Moskowitz, Julie Teruya-Feldstein

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.

Original language	English
Pages (from-to)	206-211
Number of pages	6
Journal	Applied Immunohistochemistry and Molecular Morphology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1097/PAI.0b013e3181c7138b
State	Published - May 2010
Externally published	Yes

Keywords

Biomarkers
Hodgkin lymphoma
Immunohistochemistry
Relapsed/refractory

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10.1097/PAI.0b013e3181c7138b

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title = "The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma",

abstract = "Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.",

keywords = "Biomarkers, Hodgkin lymphoma, Immunohistochemistry, Relapsed/refractory",

author = "Koreishi, {Aashiyana F.} and Saenz, {Adam J.} and Persky, {Dan O.} and Hayan Cui and Allison Moskowitz and Moskowitz, {Craig H.} and Julie Teruya-Feldstein",

year = "2010",

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doi = "10.1097/PAI.0b013e3181c7138b",

language = "English",

volume = "18",

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journal = "Applied Immunohistochemistry and Molecular Morphology",

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AU - Koreishi, Aashiyana F.

AU - Saenz, Adam J.

AU - Persky, Dan O.

AU - Cui, Hayan

AU - Moskowitz, Allison

AU - Moskowitz, Craig H.

AU - Teruya-Feldstein, Julie

PY - 2010/5

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N2 - Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.

AB - Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.

KW - Biomarkers

KW - Hodgkin lymphoma

KW - Immunohistochemistry

KW - Relapsed/refractory

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JF - Applied Immunohistochemistry and Molecular Morphology

IS - 3

ER -

The role of cytotoxic and regulatory T cells in relapsed/refractory hodgkin lymphoma

Abstract

Keywords

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