TY - JOUR
T1 - The role of criterion A2 in the DSM-IV diagnosis of posttraumatic stress disorder
AU - Karam, Elie George
AU - Andrews, Gavin
AU - Bromet, Evelyn
AU - Petukhova, Maria
AU - Ruscio, Ayelet Meron
AU - Salamoun, Mariana
AU - Sampson, Nancy
AU - Stein, Dan J.
AU - Alonso, Jordi
AU - Andrade, Laura Helena
AU - Angermeyer, Matthias
AU - Demyttenaere, Koen
AU - De Girolamo, Giovanni
AU - De Graaf, Ron
AU - Florescu, Silvia
AU - Gureje, Oye
AU - Kaminer, Debra
AU - Kotov, Roman
AU - Lee, Sing
AU - Lpine, Jean Pierre
AU - Medina-Mora, Maria Elena
AU - Oakley Browne, Mark A.
AU - Posada-Villa, Jos
AU - Sagar, Rajesh
AU - Shalev, Arieh Y.
AU - Takeshima, Tadashi
AU - Tomov, Toma
AU - Kessler, Ronald C.
N1 - Funding Information:
This report is carried out in conjunction with the World Health Organization (WHO) World Mental Health Survey Initiative. We thank the World Mental Health staff for assistance with instrumentation, field work, and data analysis. These activities were supported by the United States National Institute of Mental Health ( R01MH070884 ), the John D. and Catherine T. MacArthur Foundation , the Pfizer Foundation , the US Public Health Service ( R13-MH066849 , R01-MH069864 , and R01 DA016558 ), the Fogarty International Center ( R03-TW006481 ), the Pan American Health Organization , the Eli Lilly & Company Foundation , Ortho-McNeil Pharmaceutical Inc. , GlaxoSmithKline , Bristol-Myers Squibb , and Shire . A complete list of World Mental Health publications can be found at http://www.hcp.med.harvard.edu/wmh/ . The São Paulo Megacity Mental Health Survey is supported by the State of São Paulo Research Foundation Thematic Project Grant 03/00204-3 . The Bulgarian Epidemiological Study of Common Mental Disorders is supported by the Ministry of Health and the National Center for Public Health Protection . The Chinese World Mental Health Survey Initiative is supported by the Pfizer Foundation . The Colombian National Study of Mental Health is supported by the Ministry of Social Protection . The European Study Of The Epidemiology Of Mental Disorders project is funded by the European Commission (Contracts QLG5-1999-01042 ; SANCO 2004123 ); the Piedmont Region (Italy); Fondo de Investigación Sanitaria, Instituto de Salud Carlos III , Spain ( FIS 00/0028 ); Ministerio de Ciencia y Tecnología , Spain ( SAF 2000-158-CE ); Departament de Salut, Generalitat de Catalunya , Spain, Instituto de Salud Carlos III (Centro de Investigación Biomédica en Red CB06/02/0046 , Redes Temáticas de Investigación Cooperativa en Salud RD06/0011 Red de Enfermedades Mentales), and other local agencies and by an unrestricted educational grant from GlaxoSmithKline . The World Mental Health India was funded by WHO (India) and helped by Dr. R. Chandrasekaran, Jawaharlal Institute of Postgraduate Medical Education & Reseach. The Israel National Health Survey is funded by the Ministry of Health with support from the Israel National Institute for Health Policy and Health Services Research and the National Insurance Institute of Israel . The World Mental Health Japan Survey is supported by the Grant for Research on Psychiatric and Neurological Diseases and Mental Health ( H13-SHOGAI-023 , H14-TOKUBETSU-026 , H16-KOKORO-013 ) from the Japan Ministry of Health, Labour and Welfare . The Lebanese National Mental Health Survey LEBANON is supported by the Lebanese Ministry of Public Health , the WHO (Lebanon), Fogarty International , anonymous private donations to Institute for Development, Research, Advocacy & Applied Care, Lebanon, and unrestricted grants from Janssen Cilag , Eli Lilly , GlaxoSmithKline , Roche , and Novartis . The Mexican National Comorbidity Survey is supported by The National Institute of Psychiatry Ramon de la Fuente (Instituto Nacional de Psiquiatria Ramon de la Fuente Muniz Direccion de Investigaciones Epidemiologicas y Sociales 4280 ) and by the National Council on Science and Technology ( CONACyT-G30544-H ), with supplemental support from the PanAmerican Health Organization . Te Rau Hinengaro: The New Zealand Mental Health Survey is supported by the New Zealand Ministry of Health , Alcohol Advisory Council , and the Health Research Council . The Nigerian Survey of Mental Health and Wellbeing is supported by the WHO (Geneva), the WHO (Nigeria), and the Federal Ministry of Health , Abuja, Nigeria. The Romania World Mental Health study projects “Policies in Mental Health Area” and “National Study Regarding Mental Health and Services Use” were carried out by National School of Public Health & Health Services Management (former National Institute for Research & Development in Health), with technical support of Metro Media Transilvania , the National Institute of Statistics-National Centre for Training in Statistics , Statistics contract 70 , Cheyenne Services Societate cu Responsabilitate Limitata , and Statistics Netherlands and were funded by Ministry of Public Health (former Ministry of Health) with supplemental support of Eli Lilly , Romania Societate cu Responsabilitate Limitata . The South Africa Stress and Health Study is supported by the US National Institute of Mental Health ( R01-MH059575 ) and National Institute of Drug Abuse with supplemental funding from the South African Department of Health and the University of Michigan . The Ukraine Comorbid Mental Disorders during Periods of Social Disruption study is funded by the US National Institute of Mental Health ( RO 1-MH61905 ). The US National Comorbidity Survey Replication is supported by the National Institute of Mental Health ( U01-MH60220 ) with supplemental support from the National Institute of Drug Abuse , the Substance Abuse and Mental Health Services Administration , the Robert Wood Johnson Foundation (Grant 044708 ), and the John W. Alden Trust .
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Background: Controversy exists about the utility of DSM-IV posttraumatic stress disorder (PTSD) criterion A2 (A2): that exposure to a potentially traumatic experience (PTE; PTSD criterion A1) is accompanied by intense fear, helplessness, or horror. Methods: Lifetime DSM-IV PTSD was assessed with the Composite International Diagnostic Interview in community surveys of 52,826 respondents across 21 countries in the World Mental Health Surveys. Results: Of 28,490 representative PTEs reported by respondents, 37.6% met criterion A2, a proportion higher than the proportions meeting other criteria (BF; 5.4%9.6%). Conditional prevalence of meeting all other criteria for a diagnosis of PTSD given a PTE was significantly higher in the presence (9.7%) than absence (.1%) of A2. However, as only 1.4% of respondents who met all other criteria failed A2, the estimated prevalence of PTSD increased only slightly (from 3.64% to 3.69%) when A2 was not required for diagnosis. Posttraumatic stress disorder with or without criterion A2 did not differ in persistence or predicted consequences (subsequent suicidal ideation or secondary disorders) depending on presence-absence of A2. Furthermore, as A2 was by far the most commonly reported symptom of PTSD, initial assessment of A2 would be much less efficient than screening other criteria in quickly ruling out a large proportion of noncases. Conclusions: Removal of A2 from the DSM-IV criterion set would reduce the complexity of diagnosing PTSD, while not substantially increasing the number of people who qualify for diagnosis. Criterion A2 should consequently be reconceptualized as a risk factor for PTSD rather than as a diagnostic requirement.
AB - Background: Controversy exists about the utility of DSM-IV posttraumatic stress disorder (PTSD) criterion A2 (A2): that exposure to a potentially traumatic experience (PTE; PTSD criterion A1) is accompanied by intense fear, helplessness, or horror. Methods: Lifetime DSM-IV PTSD was assessed with the Composite International Diagnostic Interview in community surveys of 52,826 respondents across 21 countries in the World Mental Health Surveys. Results: Of 28,490 representative PTEs reported by respondents, 37.6% met criterion A2, a proportion higher than the proportions meeting other criteria (BF; 5.4%9.6%). Conditional prevalence of meeting all other criteria for a diagnosis of PTSD given a PTE was significantly higher in the presence (9.7%) than absence (.1%) of A2. However, as only 1.4% of respondents who met all other criteria failed A2, the estimated prevalence of PTSD increased only slightly (from 3.64% to 3.69%) when A2 was not required for diagnosis. Posttraumatic stress disorder with or without criterion A2 did not differ in persistence or predicted consequences (subsequent suicidal ideation or secondary disorders) depending on presence-absence of A2. Furthermore, as A2 was by far the most commonly reported symptom of PTSD, initial assessment of A2 would be much less efficient than screening other criteria in quickly ruling out a large proportion of noncases. Conclusions: Removal of A2 from the DSM-IV criterion set would reduce the complexity of diagnosing PTSD, while not substantially increasing the number of people who qualify for diagnosis. Criterion A2 should consequently be reconceptualized as a risk factor for PTSD rather than as a diagnostic requirement.
KW - Composite International Diagnostic Interview (CIDI)
KW - DSM-IV
KW - World Health Organization World Mental Health (WMH) Surveys
KW - criterion A2
KW - diagnosis
KW - posttraumatic stress disorder (PTSD)
KW - potentially traumatic experience (PTE)
UR - https://www.scopus.com/pages/publications/77955665192
U2 - 10.1016/j.biopsych.2010.04.032
DO - 10.1016/j.biopsych.2010.04.032
M3 - Article
C2 - 20599189
AN - SCOPUS:77955665192
SN - 0006-3223
VL - 68
SP - 465
EP - 473
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 5
ER -