TY - JOUR
T1 - The role of chemokines in Hodgkin's disease
AU - Teruya-Feldstein, Julie
AU - Tosato, Giovanna
AU - Jaffe, Elaine S.
N1 - Funding Information:
aFrom the Department of Pathology, Memorial Hospital, Memorial Sloan-Kettering Cancer Cente,: New York, New York 10021, bL.abora- tory of Pathology, Hematopathology Section, National Cancer Institute, National lnstitutes of Health, Bethesda, MD 20892 and ‘the Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892
PY - 2000
Y1 - 2000
N2 - Recent studies have analyzed the expression of chemokines in tissues involved by Hodgkin's disease (HD). The data indicate a significant role for chemokine expression in the pathobiology and pathophysiology of HD. In general, HD tissues showed higher levels of chemokine expression than reactive lymphoid hyperplasia (RLH) tissues. There were major differences in chemokine expression among the different HD subtypes. Similar to previous studies in athymic mice that identified a pattern of chemokine response induced by Epstein-Barr virus (EBV)-infected cells, the expression of IP-10, Mig, RANTES, and MIP1-α was higher in EBV positive compared to EBV negative HD tissues. In addition, there was a direct correlation of eotaxin expression with tissue eosinophilia. By immunohistochemistry, IP-10 and Mig proteins localized in the malignant Reed-Sternberg (RS) cells and their variants, and to some surrounding inflammatory cells. Eotaxin localized to fibroblasts and smooth muscle of blood vessels. In this review, we discuss the patterns of expression of IP-10, Mig, RANTES, MIP1-α, and eotaxin in HD and its subtypes, and the relationship to EBV positivity, LMP1 expression, tissue eosinophilia and T cell infiltration. In addition, we discuss the potential role of chemokines and cytokines in the pathobiology of HD.
AB - Recent studies have analyzed the expression of chemokines in tissues involved by Hodgkin's disease (HD). The data indicate a significant role for chemokine expression in the pathobiology and pathophysiology of HD. In general, HD tissues showed higher levels of chemokine expression than reactive lymphoid hyperplasia (RLH) tissues. There were major differences in chemokine expression among the different HD subtypes. Similar to previous studies in athymic mice that identified a pattern of chemokine response induced by Epstein-Barr virus (EBV)-infected cells, the expression of IP-10, Mig, RANTES, and MIP1-α was higher in EBV positive compared to EBV negative HD tissues. In addition, there was a direct correlation of eotaxin expression with tissue eosinophilia. By immunohistochemistry, IP-10 and Mig proteins localized in the malignant Reed-Sternberg (RS) cells and their variants, and to some surrounding inflammatory cells. Eotaxin localized to fibroblasts and smooth muscle of blood vessels. In this review, we discuss the patterns of expression of IP-10, Mig, RANTES, MIP1-α, and eotaxin in HD and its subtypes, and the relationship to EBV positivity, LMP1 expression, tissue eosinophilia and T cell infiltration. In addition, we discuss the potential role of chemokines and cytokines in the pathobiology of HD.
KW - Chemokines
KW - Eotaxin
KW - Hodgkin's disease
KW - IP-10
KW - MIP1-α
KW - Rantes
UR - http://www.scopus.com/inward/record.url?scp=0034123034&partnerID=8YFLogxK
U2 - 10.3109/10428190009087027
DO - 10.3109/10428190009087027
M3 - Article
C2 - 10830743
AN - SCOPUS:0034123034
SN - 1042-8194
VL - 38
SP - 363
EP - 371
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 3-4
ER -