The role of cancer stem cells in the anti-carcinogenicity of curcumin

Leonie Norris, Ankur Karmokar, Lynne Howells, William P. Steward, Andreas Gescher, Karen Brown

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Many cancers contain cell subpopulations that display characteristics of stem cells. These cells are characterised by their ability to self-renew, form differentiated progeny and develop resistance to chemotherapeutic strategies. Cancer stem cells may utilise many of the same signalling pathways as normal stem cells including Wnt, Notch and Hedgehog. The dietary agent curcumin exerts a plethora of anti-carcinogenic effects both in vitro and in vivo, and can also inhibit many of the signalling pathways associated with stem cell biology. Emerging evidence suggests that curcumin can exert its anti-carcinogenic activity via targeting cancer stem cells through the disruption of stem cell signalling pathways. In this review we summarise the ability of curcumin to interfere with signalling pathways Wnt, Hedgehog, Notch, Signal Transducers and Activator (STAT) and interleukin-8, and report curcumin-induced changes in function and properties of cancer stem cells. We present evidence that the effects of curcumin on cancer stem cells mediate, or contribute to, its anti-carcinogenic activity.

Original languageEnglish
Pages (from-to)1630-1637
Number of pages8
JournalMolecular Nutrition and Food Research
Volume57
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • Cancer chemoprevention
  • Cancer stem cell
  • Carcinogenesis
  • Curcumin
  • Dietary agent

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