The role of calcineurin in lymphocyte activation

Shairaz Baksh, Steven J. Burakoff

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Lymphokine gene transcription involves numerous signal transduction molecules and second messengers. The serine/threonine phosphatase calcineurin has been demonstrated to play a central role in the immediate, early activation of numerous lymphokines (such as interleukin [IL]-2) and in the regulation of cell surface receptors such as CD40L, CD95, and recently CD25α (the α chain of the IL-2 receptor). In addition to lymphocyte activation, calcineurin functions include control of neuronal signaling, muscle contraction, muscle hypertrophy and cellular death. Therefore, calcineurin not only plays a vital role in the regulation of T lymphocyte function, but also functions in cellular environments outside the immune system. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)405-415
Number of pages11
JournalSeminars in Immunology
Issue number4
StatePublished - 2000
Externally publishedYes


  • Apoptosis
  • Calcineurin
  • Immunophilins
  • NFAT
  • T lymphocyte


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