The role of 5-HT(1A) receptors in mediating the anxiogenic effects of nicotine following lateral septal administration

S. Cheeta, P. J. Kenny, S. E. File

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46 Scopus citations

Abstract

The purpose of the present study was to determine the role of the 5-HT(1A) receptors in the lateral septum in the mediation of the anxiogenic effects of nicotine in the social interaction and elevated plus maze tests of anxiety in the rat. Bilateral infusion of (-)-nicotine (4 and 8 μg) and of the 5-HT(1A) receptor agonist 8-OH-DPAT (200 and 500 ng) into the lateral septum decreased the time spent in social interaction, indicating anxiogenic effects. The anxiogenic effect of 8-OH-DPAT (500 ng) was completely reversed by coadministration of a behaviourally inactive dose of the 5-HT(1A) receptor antagonist, WAY 100635 (200 ng). The anxiogenic effect of the lower dose of (-)-nicotine (4 μg) was completely reversed by WAY 100635 (200 ng), but the reversal was only partial following administration of 8 μg nicotine. In a second test of anxiety, the elevated plus maze, lateral septal administration of 8-OH-DPAT (500 ng) and nicotine (4 μg) induced anxiogenic effects. In this test, the anxiogenic effect of nicotine (4 μg) was completely reversed by coadministration of WAY 100635 (200 ng). The effects of 8-OH-DPAT demonstrate that stimulation of 5-HT(1A) receptors in the lateral septum has anxiogenic effects in two animal tests and that the anxiogenic effects of nicotine are mediated at least in part by these 5-HT(1A) receptors.

Original languageEnglish
Pages (from-to)3797-3802
Number of pages6
JournalEuropean Journal of Neuroscience
Volume12
Issue number10
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • 8-OH-DPAT
  • Anxiety
  • Plus-maze
  • Rat
  • Social interaction

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