The rigid amphipathic fusion inhibitor dUY11 acts through photosensitization of viruses

Frederic Vigant, Axel Hollmann, Jihye Lee, Nuno C. Santos, Michael E. Jung, Benhur Lee

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen (1O2), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.

Original languageEnglish
Pages (from-to)1849-1853
Number of pages5
JournalJournal of Virology
Volume88
Issue number3
DOIs
StatePublished - Feb 2014
Externally publishedYes

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