The rest is silence

Emily Bernstein, Ahmet M. Denli, Gregory J. Hannon

Research output: Contribution to journalReview articlepeer-review

191 Scopus citations


Over the past several years, RNAi and its related phenomena have emerged not only as a powerful experimental tool but also as a new mode of gene regulation. Through a combination of genetic and biochemical approaches we have learned much about the mechanisms underlying dsRNA responces. However, many of the most intriguing aspects of dsRNA-induced gene silencing have yet to be illuminated. What has become abundantly clear is that the complex and highly conserved biology underlying RNA interference is critical both for genome maintenance and for the development of complex organisms. However, it seems probable that we have only begun to reveal the diversity of biological roles played by RNAi-related process.

Original languageEnglish
Pages (from-to)1509-1521
Number of pages13
Issue number11
StatePublished - 2001
Externally publishedYes


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