The responses of hyperglycemic dividing Mesangial cells to heparin are mediated by the non-reducing terminal Trisaccharide

Christina P. Wang, Vincent C. Hascall, Fuming Zhang, Robert J. Linhardt, Amina Abbadi, Aimin Wang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Heparin prevents intracellular hyaluronan synthesis and subsequent autophagy in hyperglycemic dividing mesangial cells. Results: The non-reducing terminal trisaccharide of heparin is sufficient for this response. Conclusion: This heparin trisaccharide motif is exposed by the mammalian heparanase and is recognized by a receptor on dividing cells. Significance: The trisaccharide does not have the anti-coagulant properties of heparin.

Original languageEnglish
Pages (from-to)29045-29050
Number of pages6
JournalJournal of Biological Chemistry
Volume290
Issue number48
DOIs
StatePublished - 27 Nov 2015
Externally publishedYes

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