The research progress of IncRNA as CeRNA in gastric cancer

Xian Zhe Dong; Yuan Hu; Ping Liu; Yu Pan Lu

doi:10.3969/j.issn.1001-1978.2016.09.001

The research progress of IncRNA as CeRNA in gastric cancer

Xian Zhe Dong, Yuan Hu, Ping Liu, Yu Pan Lu

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Recent studies have showed that RNAs regulate each other with microRNA (miRNA) response elements ( MRKs), and this mechanism is known as "competing endogenous RNA (ceRNA ) " hypothesis. hmg noncoding RNAs(IncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Aberrant expression of IncRNAs has lwen found associated with gastric cancer, one of the most malignant tumors. Compelling evidence suggests that IncRNAs can interact with miRNAs and regulate the expression of miRNAs as ceRNAs. Several IncRNAs such as GAP1JNC, BC032469, H19, HOTAIR, FER1L4 and MKG3 have heen found to associated with miHNAs in gastric caneer(GC). It is tempting to speculate that a multitude of In-cRNAs may interrupt definitive steps in GC suppressive and oncogenic pathways. The uncovering of the underlying mechanisms of IncKNAs may l>enefil our understanding of gastric cancer's {Mithogenesis.

Original language	English
Pages (from-to)	1185-1189
Number of pages	5
Journal	Chinese Pharmacological Bulletin
Volume	32
Issue number	9
DOIs	https://doi.org/10.3969/j.issn.1001-1978.2016.09.001
State	Published - Sep 2016
Externally published	Yes

Keywords

Competing endogenous knas
Gastric cancer
Long non-coding RNAs
MiRNA response elements
MicroRNA
Target genes

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title = "The research progress of IncRNA as CeRNA in gastric cancer",

abstract = "Recent studies have showed that RNAs regulate each other with microRNA (miRNA) response elements ( MRKs), and this mechanism is known as {"}competing endogenous RNA (ceRNA ) {"} hypothesis. hmg noncoding RNAs(IncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Aberrant expression of IncRNAs has lwen found associated with gastric cancer, one of the most malignant tumors. Compelling evidence suggests that IncRNAs can interact with miRNAs and regulate the expression of miRNAs as ceRNAs. Several IncRNAs such as GAP1JNC, BC032469, H19, HOTAIR, FER1L4 and MKG3 have heen found to associated with miHNAs in gastric caneer(GC). It is tempting to speculate that a multitude of In-cRNAs may interrupt definitive steps in GC suppressive and oncogenic pathways. The uncovering of the underlying mechanisms of IncKNAs may l>enefil our understanding of gastric cancer's {Mithogenesis.",

keywords = "Competing endogenous knas, Gastric cancer, Long non-coding RNAs, MiRNA response elements, MicroRNA, Target genes",

author = "Dong, {Xian Zhe} and Yuan Hu and Ping Liu and Lu, {Yu Pan}",

year = "2016",

month = sep,

doi = "10.3969/j.issn.1001-1978.2016.09.001",

language = "English",

volume = "32",

pages = "1185--1189",

journal = "Chinese Pharmacological Bulletin",

issn = "1001-1978",

publisher = "Institute of Clinical Pharmacology",

number = "9",

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T1 - The research progress of IncRNA as CeRNA in gastric cancer

AU - Dong, Xian Zhe

AU - Hu, Yuan

AU - Liu, Ping

AU - Lu, Yu Pan

PY - 2016/9

Y1 - 2016/9

N2 - Recent studies have showed that RNAs regulate each other with microRNA (miRNA) response elements ( MRKs), and this mechanism is known as "competing endogenous RNA (ceRNA ) " hypothesis. hmg noncoding RNAs(IncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Aberrant expression of IncRNAs has lwen found associated with gastric cancer, one of the most malignant tumors. Compelling evidence suggests that IncRNAs can interact with miRNAs and regulate the expression of miRNAs as ceRNAs. Several IncRNAs such as GAP1JNC, BC032469, H19, HOTAIR, FER1L4 and MKG3 have heen found to associated with miHNAs in gastric caneer(GC). It is tempting to speculate that a multitude of In-cRNAs may interrupt definitive steps in GC suppressive and oncogenic pathways. The uncovering of the underlying mechanisms of IncKNAs may l>enefil our understanding of gastric cancer's {Mithogenesis.

AB - Recent studies have showed that RNAs regulate each other with microRNA (miRNA) response elements ( MRKs), and this mechanism is known as "competing endogenous RNA (ceRNA ) " hypothesis. hmg noncoding RNAs(IncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Aberrant expression of IncRNAs has lwen found associated with gastric cancer, one of the most malignant tumors. Compelling evidence suggests that IncRNAs can interact with miRNAs and regulate the expression of miRNAs as ceRNAs. Several IncRNAs such as GAP1JNC, BC032469, H19, HOTAIR, FER1L4 and MKG3 have heen found to associated with miHNAs in gastric caneer(GC). It is tempting to speculate that a multitude of In-cRNAs may interrupt definitive steps in GC suppressive and oncogenic pathways. The uncovering of the underlying mechanisms of IncKNAs may l>enefil our understanding of gastric cancer's {Mithogenesis.

KW - Competing endogenous knas

KW - Gastric cancer

KW - Long non-coding RNAs

KW - MiRNA response elements

KW - MicroRNA

KW - Target genes

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JO - Chinese Pharmacological Bulletin

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The research progress of IncRNA as CeRNA in gastric cancer

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Keywords

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