The repair of DNA damages induced in normal human skin fibroblasts exposed to stimulated sunlight

B. S. Rosenstein, D. L. Mitchell

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The induction and repair of DNA damages produced by exposure of normal human skin fibroblasts to the simulated sunlight produced by a solar simulator were examined. The photoproducts measured were pyrimidine dimers, E. coli endonuclease III-sensitive sites, 6-4 photoproducts, Dewar isomers, DNA-protein crosslinks, and DNA single-strand breaks. The results of these experiments serve to form a basis for the quantitation of damages induced by exposure to sunlight.

Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalRadiation Research
Volume126
Issue number3
DOIs
StatePublished - 1991
Externally publishedYes

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