The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study

EU-GEI WP2 Group

doi:10.1007/s00127-023-02513-0

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study

EU-GEI WP2 Group

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

Original language	English
Pages (from-to)	1573-1580
Number of pages	8
Journal	Social Psychiatry and Psychiatric Epidemiology
Volume	58
Issue number	10
DOIs	https://doi.org/10.1007/s00127-023-02513-0
State	Published - Oct 2023
Externally published	Yes

Keywords

Childhood adversity
Cognition
Family history of psychosis
First episode
Polygenic risk score
Psychosis

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10.1007/s00127-023-02513-0

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title = "The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study",

abstract = "This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.",

keywords = "Childhood adversity, Cognition, Family history of psychosis, First episode, Polygenic risk score, Psychosis",

author = "{EU-GEI WP2 Group} and Lucia Sideli and Monica Aas and Diego Quattrone and {La Barbera}, Daniele and {La Cascia}, Caterina and Laura Ferraro and Luis Alameda and Eva Velthorst and Giulia Trotta and Giada Tripoli and Adriano Schimmenti and Andrea Fontana and Charlotte Gayer-Anderson and Simona Stilo and Fabio Seminerio and Crocettarachele Sartorio and Giovanna Marrazzo and Antonio Lasalvia and Sarah Tosato and Ilaria Tarricone and Domenico Berardi and Giuseppe D{\textquoteright}Andrea and Silvia Amoretti and {\'A}lvaro Andreu-Bernabeu and Gr{\'e}goire Baudin and Stephanie Beards and Chiara Bonetto and Elena Bonora and Bibiana Cabrera and Angel Carracedo and Thomas Charpeaud and Javier Costas and Doriana Cristofalo and Pedro Cuadrado and Manuel Dur{\'a}n-Cutilla and Aziz Ferchiou and David Fraguas and Nathalie Franke and Flora Frijda and Paz Garcia-Portilla and {Gonz{\'a}lez Pe{\~n}as}, Javier and Kathryn Hubbard and St{\'e}phane Jamain and Estela Jim{\'e}nez-L{\'o}pez and Marion Leboyer and Cloe Llorente and {L{\'o}pez Montoya}, Gonzalo and Esther Lorente-Rovira and {M. D{\'i}az-Caneja}, Covadonga and {Marcelino Loureiro}, Camila",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = oct,

doi = "10.1007/s00127-023-02513-0",

language = "English",

volume = "58",

pages = "1573--1580",

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T1 - The relationship between genetic liability, childhood maltreatment, and IQ

T2 - findings from the EU-GEI multicentric case–control study

AU - EU-GEI WP2 Group

AU - Sideli, Lucia

AU - Aas, Monica

AU - Quattrone, Diego

AU - La Barbera, Daniele

AU - La Cascia, Caterina

AU - Ferraro, Laura

AU - Alameda, Luis

AU - Velthorst, Eva

AU - Trotta, Giulia

AU - Tripoli, Giada

AU - Schimmenti, Adriano

AU - Fontana, Andrea

AU - Gayer-Anderson, Charlotte

AU - Stilo, Simona

AU - Seminerio, Fabio

AU - Sartorio, Crocettarachele

AU - Marrazzo, Giovanna

AU - Lasalvia, Antonio

AU - Tosato, Sarah

AU - Tarricone, Ilaria

AU - Berardi, Domenico

AU - D’Andrea, Giuseppe

AU - Amoretti, Silvia

AU - Andreu-Bernabeu, Álvaro

AU - Baudin, Grégoire

AU - Beards, Stephanie

AU - Bonetto, Chiara

AU - Bonora, Elena

AU - Cabrera, Bibiana

AU - Carracedo, Angel

AU - Charpeaud, Thomas

AU - Costas, Javier

AU - Cristofalo, Doriana

AU - Cuadrado, Pedro

AU - Durán-Cutilla, Manuel

AU - Ferchiou, Aziz

AU - Fraguas, David

AU - Franke, Nathalie

AU - Frijda, Flora

AU - Garcia-Portilla, Paz

AU - González Peñas, Javier

AU - Hubbard, Kathryn

AU - Jamain, Stéphane

AU - Jiménez-López, Estela

AU - Leboyer, Marion

AU - Llorente, Cloe

AU - López Montoya, Gonzalo

AU - Lorente-Rovira, Esther

AU - M. Díaz-Caneja, Covadonga

AU - Marcelino Loureiro, Camila

PY - 2023/10

Y1 - 2023/10

N2 - This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

AB - This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

KW - Childhood adversity

KW - Cognition

KW - Family history of psychosis

KW - First episode

KW - Polygenic risk score

KW - Psychosis

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U2 - 10.1007/s00127-023-02513-0

DO - 10.1007/s00127-023-02513-0

M3 - Article

AN - SCOPUS:85162996860

SN - 0933-7954

VL - 58

SP - 1573

EP - 1580

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

IS - 10

ER -

The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study

Abstract

Keywords

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